{"id":"W2734770601","doi":"10.1038/cddis.2017.306","title":"p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Ministerio de Economía y Competitividad; Ministerio de Educación, Cultura y Deporte","keywords":"Retinitis pigmentosa; Photoreceptor cell; Retina; Outer nuclear layer; Retinal; Biology; Retinal degeneration; Cell biology; Gene therapy of the human retina; Programmed cell death; TUNEL assay; Retinal regeneration; Apoptosis; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255801,0.001018893,0.000516149,0.0008447196,0.0002335933,0.000306023,0.0004585646,0.0006489358,0.001509154],"category_scores_gemma":[0.0001555989,0.0002517817,0.0003819076,0.0002122845,0.0003670769,0.0002770857,0.0001958531,0.001227399,0.0004653696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005343871,"about_ca_system_score_gemma":0.0003053629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001407566,"about_ca_topic_score_gemma":0.002557437,"domain_scores_codex":[0.9996356,0.00006285171,0.00003943263,0.0000623934,0.0001136928,0.00008597727],"domain_scores_gemma":[0.9996915,0.00003012239,0.0001212263,0.00003293954,0.00003003227,0.00009425964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005970686,0.0003024891,0.0001067532,0.00007183165,0.00001109803,0.00009828377,0.00002561549,0.0001245136,0.9970861,0.00004877135,0.00006949127,0.001458108],"study_design_scores_gemma":[0.0001362972,0.00852941,0.004381475,0.00003361586,0.00005239432,0.000399355,0.00007911865,0.001182309,0.982732,0.00005517612,0.002406702,0.00001232132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911985,0.003551786,0.001926515,0.000136357,0.0001034048,0.000151967,0.0006336084,0.0002940063,0.002003912],"genre_scores_gemma":[0.9871348,0.002517101,0.00298832,0.0001055425,0.00002717207,0.0002317738,0.0005754377,0.00003792685,0.006381862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001509154,"threshold_uncertainty_score":0.005048633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108491105809179,"score_gpt":0.2342472090009752,"score_spread":0.2233980984200573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}