{"id":"W2734804244","doi":"10.1021/acschemneuro.7b00226","title":"Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Ministerstwo Edukacji i Nauki; Fonds Wetenschappelijk Onderzoek; Narodowe Centrum Nauki; Belgian Federal Science Policy Office","keywords":"Neuropathic pain; Analgesic; Pharmacology; Agonist; Opioid; Medicine; Substance P; Opioid receptor; Tachykinin receptor 1; Anesthesia; Receptor; Chemistry; Internal medicine; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008863428,0.0001050814,0.0002009566,0.00006650927,0.00006594384,0.00002056291,0.0001163442,0.00004297932,7.47304e-7],"category_scores_gemma":[0.000292254,0.00007160045,0.00001386485,0.0001262352,0.0004292903,0.0001471872,0.00007255927,0.0001279281,4.462892e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005137508,"about_ca_system_score_gemma":0.00009236534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001271315,"about_ca_topic_score_gemma":0.000007928036,"domain_scores_codex":[0.9991986,0.00001088358,0.000149136,0.00029196,0.0001658338,0.0001835632],"domain_scores_gemma":[0.9996038,0.00001933697,0.0000938888,0.0001901398,0.00002828782,0.00006456608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002283854,0.0001196189,0.06530424,0.00006592748,0.00000161348,0.00003025353,0.00006890784,2.838037e-7,0.933355,0.00001144032,0.000001872464,0.0008125078],"study_design_scores_gemma":[0.001038765,0.0002456531,0.09543508,0.0001993165,0.00001074524,0.00001680509,0.00002225714,0.0008362759,0.9021025,0.00002227721,0.000005367779,0.00006501029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999352,0.0001204272,0.00001071062,0.0001354245,0.0000356341,0.0002797321,0.000009150295,0.000009466524,0.00004747838],"genre_scores_gemma":[0.9996132,0.00006776398,0.0001936002,0.00005014154,0.00001396327,0.000026094,0.000002321707,0.00000622674,0.0000267042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0312525,"threshold_uncertainty_score":0.2919782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716062296836921,"score_gpt":0.2571241155741921,"score_spread":0.2399634926058229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}