{"id":"W2734805236","doi":"10.1200/jco.2017.35.15_suppl.8506","title":"Mature overall survival (OS) results from the LUME-Meso study of nintedanib (N) + pemetrexed/cisplatin (PEM/CIS) vs placebo (P) + PEM/CIS in chemo-naïve patients (pts) with malignant pleural mesothelioma (MPM).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Hazard ratio; Internal medicine; Gastroenterology; Progression-free survival; Clinical endpoint; Pemetrexed; Confidence interval; Placebo; Urology; Randomized controlled trial; Cisplatin; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002661651,0.0008279852,0.001274979,0.0003060639,0.000179342,0.0005173733,0.0004588492,0.000663001,0.002636537],"category_scores_gemma":[0.001128403,0.0003073065,0.001802493,0.0002628125,0.0004926386,0.0005212561,0.0004518509,0.001551063,0.0002860203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004984346,"about_ca_system_score_gemma":0.0004559327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005103912,"about_ca_topic_score_gemma":0.001222193,"domain_scores_codex":[0.9993149,0.0004669651,0.00003582229,0.00007651015,0.00005177548,0.0000539774],"domain_scores_gemma":[0.9990411,0.0002788447,0.0002780407,0.00006869432,0.00003615699,0.0002969564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9535074,0.003988231,0.006729211,0.0005244304,0.002307426,0.00005576018,0.00007168097,0.001084971,0.006075227,0.00006438856,0.0008947079,0.02469649],"study_design_scores_gemma":[0.4902182,0.4210911,0.07709974,0.00009565273,0.005827286,0.0001725443,0.0000479652,0.001170514,0.001907002,0.0002002816,0.002138339,0.00003140578],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926958,0.003860718,0.000308981,0.0002160718,0.00006985151,0.0004043885,0.001237318,0.00002543824,0.001181439],"genre_scores_gemma":[0.9940601,0.001670124,0.0004211453,0.0004198248,0.000151758,0.0004230758,0.001966895,0.000009517676,0.0008774485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002661651,"threshold_uncertainty_score":0.01407629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07346927153434472,"score_gpt":0.4038931658029776,"score_spread":0.3304238942686329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}