{"id":"W2734805455","doi":"10.1016/j.jtho.2017.07.005","title":"ASCEND-8: A Randomized Phase 1 Study of Ceritinib, 450 mg or 600 mg, Taken with a Low-Fat Meal versus 750 mg in Fasted State in Patients with Anaplastic Lymphoma Kinase (ALK)-Rearranged Metastatic Non–Small Cell Lung Cancer (NSCLC)","year":2017,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Merck Sharp and Dohme; Yuhan; Novartis Pharmaceuticals Corporation; AstraZeneca; Celgene; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ceritinib; Medicine; Crizotinib; Anaplastic lymphoma kinase; Gastroenterology; Tolerability; Pharmacokinetics; Internal medicine; Meal; Vomiting; Nausea; ALK inhibitor; Pharmacology; Adverse effect; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007074098,0.0003715655,0.002052448,0.0005875684,0.0001277034,0.00004294416,0.0002599262,0.00009321922,0.0001084732],"category_scores_gemma":[0.0003220651,0.0002246482,0.0001420445,0.0003316752,0.0002116896,0.0002871018,0.00004987489,0.0003530442,0.000001538913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071289,"about_ca_system_score_gemma":0.002047855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926234,"about_ca_topic_score_gemma":0.01372771,"domain_scores_codex":[0.9968582,0.0005713094,0.001179292,0.0003481839,0.0005696551,0.0004733448],"domain_scores_gemma":[0.9961678,0.0005966994,0.001961888,0.0004013031,0.0005830046,0.0002893191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8906046,0.0151554,0.047456,0.0004104497,0.002417078,0.004248999,0.009301348,0.0005119638,0.0002767554,4.864294e-7,0.00005676045,0.02956015],"study_design_scores_gemma":[0.8609176,0.03574622,0.08970653,0.001671454,0.006316467,0.00007385867,0.0039731,0.0009510965,0.0002879031,0.000004422656,0.00005956866,0.0002918085],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954807,0.0002432831,0.0001619422,0.0002223495,0.0004480809,0.002895612,0.0000852573,0.00000857362,0.0004542689],"genre_scores_gemma":[0.9977485,0.00007549059,0.001577966,0.00005557729,0.00007411207,0.0002102638,0.00001971126,0.00005257035,0.0001858169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04225053,"threshold_uncertainty_score":0.9160888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02337236563680686,"score_gpt":0.4175437570014449,"score_spread":0.3941713913646381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}