{"id":"W2734805455","doi":"10.1016/j.jtho.2017.07.005","title":"ASCEND-8: A Randomized Phase 1 Study of Ceritinib, 450 mg or 600 mg, Taken with a Low-Fat Meal versus 750 mg in Fasted State in Patients with Anaplastic Lymphoma Kinase (ALK)-Rearranged Metastatic Non–Small Cell Lung Cancer (NSCLC)","year":2017,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Merck Sharp and Dohme; Yuhan; Novartis Pharmaceuticals Corporation; AstraZeneca; Celgene; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ceritinib; Medicine; Crizotinib; Anaplastic lymphoma kinase; Gastroenterology; Tolerability; Pharmacokinetics; Internal medicine; Meal; Vomiting; Nausea; ALK inhibitor; Pharmacology; Adverse effect; Lung cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279174,0.002455706,0.003599582,0.0005181054,0.0005175336,0.001331315,0.001230734,0.001880341,0.007952938],"category_scores_gemma":[0.001226496,0.0009874363,0.002120371,0.0003896573,0.001506608,0.001719622,0.0004536138,0.004526747,0.001648443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106002,"about_ca_system_score_gemma":0.001114655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260015,"about_ca_topic_score_gemma":0.002850159,"domain_scores_codex":[0.999632,0.0001621381,0.00001666984,0.00008571604,0.00002541547,0.00007808339],"domain_scores_gemma":[0.9994509,0.0001297606,0.000101663,0.00004400681,0.00003426659,0.0002393667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9798439,0.006218624,0.0004141959,0.0003042075,0.0004761139,0.00002791912,0.00003499329,0.0004976412,0.00207231,0.0000865605,0.0009018822,0.00912171],"study_design_scores_gemma":[0.946102,0.05141846,0.0009615787,0.00001163638,0.0002795934,0.00002694105,0.00001921173,0.0004113302,0.0002713968,0.0000925481,0.0003909539,0.00001429614],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895499,0.002393482,0.0005782232,0.0007800295,0.0007050791,0.002320526,0.001330347,0.0002719987,0.002070401],"genre_scores_gemma":[0.9851281,0.002032277,0.001356006,0.001151836,0.0004593767,0.003169237,0.001966652,0.00006925387,0.004667315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007952938,"threshold_uncertainty_score":0.02660519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02337236563680686,"score_gpt":0.4175437570014449,"score_spread":0.3941713913646381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}