{"id":"W2734836672","doi":"10.1371/journal.pone.0181012","title":"Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; DNA replication; Viral replication; Molecular biology; Gene; Virus; Replication factor C; Immunoprecipitation; Control of chromosome duplication; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005053896,0.0009164267,0.0005521501,0.0005192588,0.0002745334,0.0005042285,0.0004233113,0.0004845012,0.002394265],"category_scores_gemma":[0.0002760323,0.0003554091,0.0003607092,0.0005694895,0.0003472041,0.0003571536,0.0003272597,0.000812528,0.001715454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004605187,"about_ca_system_score_gemma":0.0003497345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006932819,"about_ca_topic_score_gemma":0.0009277645,"domain_scores_codex":[0.9994375,0.0001149915,0.00008729244,0.0001196573,0.0001500976,0.000090354],"domain_scores_gemma":[0.9997706,0.00005511829,0.00005527484,0.00005198417,0.00002850462,0.00003859398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003384607,0.0000977095,0.0004444417,0.0001784627,0.00001889984,0.00006553958,0.00004592318,0.00009507268,0.9934481,0.0004128111,0.0003097305,0.004544804],"study_design_scores_gemma":[0.00005756036,0.0006668474,0.002461903,0.00002200753,0.00003710084,0.0004826811,0.00003819307,0.0007264625,0.9733041,0.0001132263,0.0220726,0.00001729407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.91545,0.008992811,0.0588316,0.0001848258,0.0004042102,0.0009541124,0.006641037,0.0009340073,0.007607302],"genre_scores_gemma":[0.9015797,0.005728838,0.04962729,0.0001862692,0.0000514649,0.0007733728,0.01615684,0.0001128245,0.02578332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394265,"threshold_uncertainty_score":0.008009613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06006783459845292,"score_gpt":0.309034009196909,"score_spread":0.2489661745984561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}