{"id":"W2734877939","doi":"10.1038/s41598-017-05656-8","title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institute of General Medical Sciences; College of Engineering, Michigan State University; National Institutes of Health; Michigan State University","keywords":"Enterohepatic circulation; Bile acid; Aryl hydrocarbon receptor; Cholesterol 7 alpha-hydroxylase; G protein-coupled bile acid receptor; CYP8B1; Metabolism; Internal medicine; Bile Salt Export Pump; Hepatocyte; FGF19; Chemistry; Endocrinology; Farnesoid X receptor; Taurocholic acid; CYP27A1; Biology; Biochemistry; Receptor; Transporter; Nuclear receptor; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374393,0.0004284528,0.0003927231,0.0003789293,0.0001841057,0.000294882,0.0001410434,0.0003596169,0.001183018],"category_scores_gemma":[0.00008688861,0.0001892156,0.0003349457,0.0003048521,0.0003205897,0.0001613072,0.0001894882,0.0005686808,0.0002902251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003911259,"about_ca_system_score_gemma":0.0003573484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331891,"about_ca_topic_score_gemma":0.002515002,"domain_scores_codex":[0.9997887,0.0000239479,0.00001464446,0.00005244828,0.00004619773,0.00007405216],"domain_scores_gemma":[0.9998671,0.0000124498,0.0000282143,0.00001201327,0.00003099163,0.00004918118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004038413,0.00004519919,0.0004370828,0.00002211477,0.000003760915,0.0000453175,0.00001663179,0.00002985715,0.9984072,0.00002751772,0.0000212892,0.0005401596],"study_design_scores_gemma":[0.00002568947,0.0009426367,0.01497325,0.000004521055,0.00001993172,0.0001225352,0.00005090956,0.0003999214,0.9825082,0.00005243702,0.0008924883,0.00000752674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954266,0.001197533,0.001148678,0.0001031339,0.0000486996,0.00003095402,0.0008992684,0.00008446527,0.001060742],"genre_scores_gemma":[0.9909104,0.001069568,0.001037252,0.0001450081,0.0000154121,0.00006304486,0.001130907,0.00002231555,0.005606083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331891,"threshold_uncertainty_score":0.003957629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182706185578496,"score_gpt":0.2491283920696157,"score_spread":0.2373013302138308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}