{"id":"W2734896856","doi":"10.1210/en.2017-00287","title":"Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway","year":2017,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research; National Science and Technology Major Project; China Scholarship Council; BC Children's Hospital","keywords":"Signal transduction; Glycogen synthase; Internal medicine; Endocrinology; GSK-3; Prostaglandin E2; Phosphorylation; GSK3B; Forskolin; Downregulation and upregulation; Chemistry; Cell biology; Protein kinase A; Kinase; Granulosa cell; Biology; Ovary; Stimulation; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408268,0.0001880933,0.0003323593,0.0002254927,0.0001867252,0.0002929365,0.0001075863,0.0002241253,0.001329625],"category_scores_gemma":[0.00009233603,0.0001158161,0.0003268353,0.0002708655,0.0001977642,0.0001345791,0.0001515564,0.0004354273,0.0003786854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327297,"about_ca_system_score_gemma":0.000295844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130127,"about_ca_topic_score_gemma":0.001822198,"domain_scores_codex":[0.9998573,0.00001948364,0.00002205723,0.00002134967,0.00004572134,0.00003400389],"domain_scores_gemma":[0.9999422,0.00001091253,0.00001649175,0.000008333609,0.000007515975,0.00001455539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004889141,0.0001593348,0.0009065901,0.0001303037,0.00001216609,0.0001669838,0.00006583081,0.00005822072,0.9949651,0.00007681809,0.000240976,0.002728722],"study_design_scores_gemma":[0.0001654981,0.001651771,0.01487194,0.00002014662,0.00006511978,0.0004707463,0.0001386543,0.001233205,0.9733304,0.00006315877,0.007978172,0.00001122763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909937,0.004019137,0.00141061,0.0002736179,0.00007125799,0.00005694369,0.0007719779,0.0001475228,0.002255378],"genre_scores_gemma":[0.9914162,0.001806514,0.00184561,0.0001990054,0.00002686806,0.00009115078,0.00140125,0.00001510241,0.003198434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329625,"threshold_uncertainty_score":0.004448056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009685016039629901,"score_gpt":0.2474815928354954,"score_spread":0.2377965767958655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}