{"id":"W2734948797","doi":"10.1016/j.brainres.2017.07.009","title":"Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18FDG retention in 5XFAD mouse model of Alzheimer’s disease","year":2017,"lang":"en","type":"article","venue":"Brain Research","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Genetically modified mouse; Endocrinology; Internal medicine; Alzheimer's disease; Amyloid (mycology); Neuroscience; Pathogenesis; Chemistry; Cholinergic; Cerebellum; Transgene; Pathology; Biology; Acetylcholinesterase; Medicine; Biochemistry; Aché; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006637305,0.001575256,0.000874539,0.001874131,0.0006321435,0.0009216971,0.0007970466,0.001461857,0.002972875],"category_scores_gemma":[0.000227493,0.0006968583,0.0008587267,0.0004399455,0.001086538,0.001184666,0.0004466844,0.001989389,0.0007488949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005796786,"about_ca_system_score_gemma":0.000480613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002404928,"about_ca_topic_score_gemma":0.003497328,"domain_scores_codex":[0.9995087,0.0000614698,0.00008461889,0.0001179836,0.00008496458,0.0001421972],"domain_scores_gemma":[0.9994004,0.00005311856,0.0002471507,0.00006074411,0.00005510755,0.0001835024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008411707,0.0001936202,0.0002106803,0.00005227026,0.00002988165,0.0002487269,0.00005377937,0.00003952424,0.9972661,0.0002645675,0.00008517979,0.000714599],"study_design_scores_gemma":[0.0001668282,0.0007470576,0.006334786,0.00003452082,0.0001881464,0.0013036,0.0001959036,0.0008150026,0.9872878,0.0003162118,0.002586034,0.00002422842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925148,0.001904414,0.003058556,0.0003786611,0.0001375411,0.00004170336,0.0007678802,0.0002098822,0.0009865288],"genre_scores_gemma":[0.9800434,0.002348546,0.004943342,0.0001997857,0.00005108738,0.0001224784,0.001144428,0.0002213198,0.01092567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002972875,"threshold_uncertainty_score":0.009945273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2474142047620244,"score_gpt":0.4411012314923513,"score_spread":0.1936870267303269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}