{"id":"W2734992862","doi":"10.1016/j.colsurfb.2017.07.044","title":"The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: Synthesis, characterization and cytotoxicity studies","year":2017,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Science Research and Technology; Iran National Science Foundation","keywords":"Cytotoxicity; Chitosan; Prodigiosin; Chemistry; Cyclodextrin; Drug delivery; Anticancer drug; Magnetic nanoparticles; Drug; Nanoparticle; Combinatorial chemistry; Pharmacology; Biochemistry; Nanotechnology; Organic chemistry; In vitro; Materials science; Medicine; Serratia marcescens","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583589,0.0002130693,0.0001376512,0.0001284409,0.00008437166,0.0001487518,0.000140884,0.0002405149,0.000491152],"category_scores_gemma":[0.0002438005,0.0001458264,0.0001647444,0.0001022923,0.0001813641,0.0001713134,0.00008305705,0.0002482668,0.0001644524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000284751,"about_ca_system_score_gemma":0.0001625897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018728,"about_ca_topic_score_gemma":0.001144613,"domain_scores_codex":[0.9999038,0.00001069803,0.00001095931,0.00002777289,0.00002813907,0.00001860212],"domain_scores_gemma":[0.9998844,0.00002683909,0.00003399171,0.00001120274,0.00002697879,0.00001664612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007261668,0.000007414641,0.00004661859,0.00001290824,0.00000192406,0.00001715832,0.000008077235,0.00004949238,0.9992799,0.0000231978,0.00001019277,0.0004704325],"study_design_scores_gemma":[0.000003739509,0.00007166845,0.0004227133,6.905801e-7,0.000003465219,0.00003226077,0.000002459607,0.0003777648,0.9989011,0.000003638881,0.0001783888,0.00000204951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964197,0.0005504162,0.002110549,0.00003205572,0.00001382541,0.00002123171,0.00008559955,0.00002874361,0.0007379741],"genre_scores_gemma":[0.9975986,0.0001742499,0.001028706,0.00001592329,0.000002823722,0.00001100745,0.00006996746,0.000008258696,0.001090363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018728,"threshold_uncertainty_score":0.002066016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009803087257595629,"score_gpt":0.2499698689900332,"score_spread":0.2401667817324376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}