{"id":"W2734992862","doi":"10.1016/j.colsurfb.2017.07.044","title":"The enzyme-sensitive release of prodigiosin grafted β-cyclodextrin and chitosan magnetic nanoparticles as an anticancer drug delivery system: Synthesis, characterization and cytotoxicity studies","year":2017,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Science Research and Technology; Iran National Science Foundation","keywords":"Cytotoxicity; Chitosan; Prodigiosin; Chemistry; Cyclodextrin; Drug delivery; Anticancer drug; Magnetic nanoparticles; Drug; Nanoparticle; Combinatorial chemistry; Pharmacology; Biochemistry; Nanotechnology; Organic chemistry; In vitro; Materials science; Medicine; Serratia marcescens","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990854,0.000161733,0.000233977,0.00002035224,0.0006343957,0.0001761998,0.0001354043,0.00005659766,6.377363e-7],"category_scores_gemma":[0.0001140314,0.0001163383,0.00002364048,0.00003359852,0.0006797679,0.0000257573,0.0001877623,0.00004116975,4.129425e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003637308,"about_ca_system_score_gemma":0.00002794406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001495592,"about_ca_topic_score_gemma":0.0002345966,"domain_scores_codex":[0.9990901,0.0001017868,0.0002199759,0.0003444119,0.00007296373,0.0001707953],"domain_scores_gemma":[0.9992751,0.00004486336,0.0001884399,0.0003234509,0.00008700114,0.00008107437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489743,0.00002759491,0.004039696,0.00008091205,0.00004691993,6.580191e-7,0.0002121809,9.336876e-7,0.9912031,0.00009675574,0.00001832296,0.004123985],"study_design_scores_gemma":[0.0002521101,0.0001310665,0.05671909,0.00009837216,0.00006452837,0.00001026969,0.00114871,0.0002287193,0.9407349,0.00001362434,0.0004541056,0.0001445457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900969,0.009002028,0.00001193262,0.0002973971,0.00005669389,0.0003756511,0.0001137271,0.00001070113,0.00003492988],"genre_scores_gemma":[0.9868752,0.01279421,0.0001051275,0.00001952127,0.00003695947,0.00003019349,0.000006299903,0.00001170131,0.0001208133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0526794,"threshold_uncertainty_score":0.4879323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009803087257595629,"score_gpt":0.2499698689900332,"score_spread":0.2401667817324376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}