{"id":"W2735104323","doi":"10.1016/j.neuropharm.2017.07.008","title":"Inhibition of TrkB at the nucleus accumbens, using ANA-12, regulates basal and stress-induced orexin A expression within the mesolimbic system and affects anxiety, sociability and motivation","year":2017,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleus accumbens; Ventral tegmental area; Tropomyosin receptor kinase B; Orexin; Conditioned place preference; Psychology; Neuroscience; Neurotrophic factors; Internal medicine; Endocrinology; Receptor; Neuropeptide; Addiction; Central nervous system; Medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761474,0.000857769,0.0008096487,0.0004091351,0.0005112101,0.0006350033,0.0006076446,0.0005501455,0.003545194],"category_scores_gemma":[0.0002336953,0.0005998456,0.000626891,0.0002181545,0.001202723,0.0005967188,0.0003090547,0.002633814,0.0007651387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007628589,"about_ca_system_score_gemma":0.000855057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003255822,"about_ca_topic_score_gemma":0.01099361,"domain_scores_codex":[0.9997205,0.00002667043,0.00001810069,0.00005781602,0.00004769465,0.000129143],"domain_scores_gemma":[0.9997454,0.00001929782,0.0000600347,0.00002334032,0.00001943716,0.0001324646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003307252,0.0004049374,0.0002258098,0.00004294516,0.00002394107,0.00004245945,0.00003004676,0.0001253339,0.9930136,0.000146138,0.0001896073,0.002448081],"study_design_scores_gemma":[0.0005524743,0.003892672,0.006591447,0.00001507874,0.00007460068,0.0002298496,0.0001200227,0.002535097,0.9844691,0.0002017473,0.001280995,0.00003692068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996379,0.0003276782,0.001419765,0.0002389723,0.00009096198,0.00004298141,0.0002637427,0.0002317927,0.001005153],"genre_scores_gemma":[0.9903054,0.0005714993,0.002351862,0.00008821273,0.00004133241,0.00008766868,0.000291329,0.00009668059,0.006165974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003545194,"threshold_uncertainty_score":0.01185983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06626667097037658,"score_gpt":0.3319998769550134,"score_spread":0.2657332059846368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}