{"id":"W2735193465","doi":"10.1002/glia.23179","title":"Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation","year":2017,"lang":"en","type":"article","venue":"Glia","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Neuroactive steroid; Dehydroepiandrosterone; Experimental autoimmune encephalomyelitis; Neuroinflammation; Multiple sclerosis; Oligodendrocyte; Immunology; Encephalomyelitis; Central nervous system; Endocrinology; Biology; Myelin; Pharmacology; Internal medicine; Medicine; Inflammation; Androgen; Receptor; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454476,0.0003356463,0.0002974439,0.0003616949,0.0001869149,0.000357203,0.0001753805,0.0002687533,0.0009544889],"category_scores_gemma":[0.0001009786,0.00007599333,0.0002143968,0.0002184307,0.0004755095,0.0002046909,0.0002080128,0.0003387317,0.0002317708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003355132,"about_ca_system_score_gemma":0.0002943374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009456353,"about_ca_topic_score_gemma":0.001445607,"domain_scores_codex":[0.9999264,0.00001240167,0.000007632219,0.00001660401,0.00001859029,0.00001836684],"domain_scores_gemma":[0.9998912,0.000008660925,0.00003023243,0.00001080785,0.00001966519,0.00003942202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004930424,0.00003489395,0.002092439,0.0001578481,0.00001541503,0.0003138605,0.00006705117,0.00004801094,0.9913238,0.0001923234,0.0000647616,0.005196528],"study_design_scores_gemma":[0.0001051885,0.001946778,0.1329051,0.00009489564,0.0001478123,0.003388872,0.0005236803,0.0005708936,0.8417109,0.001229385,0.01734996,0.00002656818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655025,0.03057882,0.001352564,0.0003876648,0.00006856283,0.00002026609,0.0003655987,0.00006599436,0.001657984],"genre_scores_gemma":[0.9869543,0.01056358,0.00060326,0.00009690403,0.00004952566,0.00001497577,0.0001669361,0.000008777569,0.001541709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009544889,"threshold_uncertainty_score":0.003193021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.131821377841393,"score_gpt":0.302806831778811,"score_spread":0.170985453937418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}