{"id":"W2735208690","doi":"10.1084/jem.20162040","title":"Protein kinase D at the Golgi controls NLRP3 inflammasome activation","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Institute of Genetics; Laboratoire d'Excellence INRT; Chinese Diabetes Society; Universitetet i Oslo; Eli Lilly and Company; Universität Stuttgart; European Foundation for the Study of Diabetes; Agence Nationale de la Recherche; European Commission; Université de Strasbourg; Horizon 2020 Framework Programme","keywords":"Inflammasome; Golgi apparatus; Endoplasmic reticulum; Cell biology; Effector; Pyroptosis; Diacylglycerol kinase; Innate immune system; Protein kinase A; Chemistry; Biology; Phosphorylation; Protein kinase C; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172238,0.0003756348,0.0003724575,0.0003072743,0.0003004894,0.0007751439,0.0002773186,0.0005348934,0.001628262],"category_scores_gemma":[0.0002676504,0.0001935997,0.0003917735,0.0002205357,0.0005634744,0.0006103561,0.0005072943,0.0007590026,0.0007554649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007670278,"about_ca_system_score_gemma":0.000461886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005266743,"about_ca_topic_score_gemma":0.0004303845,"domain_scores_codex":[0.999761,0.00004250357,0.00003277872,0.00006152949,0.00003211767,0.00007013946],"domain_scores_gemma":[0.999817,0.00002059354,0.00005640723,0.00002548318,0.00002122809,0.00005936182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008289395,0.00002725176,0.0002827511,0.00006590057,0.000005019309,0.0001331151,0.00001999402,0.00008968727,0.9974768,0.0003079851,0.00006470161,0.0006979838],"study_design_scores_gemma":[0.0001345949,0.000155429,0.008083831,0.00001887697,0.00002803734,0.0006865222,0.0001536925,0.001841612,0.9852152,0.0006194341,0.003046937,0.00001586209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866746,0.004948175,0.004242586,0.0005969136,0.0001734439,0.00003185399,0.0008515202,0.0001580958,0.002322707],"genre_scores_gemma":[0.9968136,0.0009887605,0.001069171,0.00007813795,0.000009707787,0.00001477905,0.0002321612,0.00002618304,0.0007675451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628262,"threshold_uncertainty_score":0.005565166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226531323594289,"score_gpt":0.2834728041511465,"score_spread":0.2712074909152036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}