{"id":"W2735237065","doi":"10.1016/j.vaccine.2017.07.012","title":"Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages","year":2017,"lang":"en","type":"article","venue":"Vaccine","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medicago (Canada); Montreal General Hospital; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Hemagglutinin (influenza); Immunogenicity; Biology; Virology; Virus; Lectin; Antigen; Virus-like particle; Sialic acid; Microbiology; Influenza A virus; Neuraminidase; Cell biology; Molecular biology; Immunology; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979245,0.0002331481,0.0001851532,0.0001421316,0.0001465325,0.0002481019,0.0002080292,0.000314307,0.0006534779],"category_scores_gemma":[0.0001316942,0.0001272474,0.0002341597,0.00007728321,0.0002331147,0.0002340273,0.0001349767,0.0006567939,0.000358998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002316568,"about_ca_system_score_gemma":0.0001248844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005231378,"about_ca_topic_score_gemma":0.0008167042,"domain_scores_codex":[0.9998813,0.00003173217,0.000007359506,0.00002002732,0.00002673666,0.00003282637],"domain_scores_gemma":[0.999909,0.0000330904,0.0000143753,0.00001825277,0.00001036864,0.00001485946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459467,0.00002667425,0.00009692617,0.000009774633,0.000003149829,0.00002905229,0.00001735301,0.00003978491,0.9992174,0.0000660681,0.00001414189,0.0003337904],"study_design_scores_gemma":[0.00001983851,0.0006096661,0.003088245,0.000002695431,0.00001287113,0.0002203705,0.00003957991,0.0007832546,0.9941855,0.00005163942,0.0009832209,0.000003073198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958496,0.000480607,0.002741056,0.00004247413,0.00003261242,0.00002915588,0.0001190575,0.00003035837,0.0006750246],"genre_scores_gemma":[0.9961265,0.0002178659,0.002143099,0.00003719839,0.00001159634,0.00002379789,0.0002219418,0.00001463491,0.001203288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006534779,"threshold_uncertainty_score":0.00218612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1054269411119748,"score_gpt":0.3978571061099476,"score_spread":0.2924301649979728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}