{"id":"W2735367257","doi":"10.1038/mp.2017.142","title":"Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation","year":2017,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto; Krembil Foundation; University Health Network","funders":"Ministerio de Economía y Competitividad; Euskal Herriko Unibertsitatea; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Autophagy; Neuroscience; Pathology; Medicine; Psychology; Chemistry; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260034,0.0002209666,0.0002963683,0.00008029803,0.000339377,0.0000540613,0.0001590984,0.0001658554,0.00003344004],"category_scores_gemma":[0.00004645575,0.0002039743,0.000122527,0.00004861454,0.0001666401,0.0001276592,0.00007025532,0.0002598875,0.00003806139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002880721,"about_ca_system_score_gemma":0.00013782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001173861,"about_ca_topic_score_gemma":0.000008965563,"domain_scores_codex":[0.9988251,0.00007975017,0.0001643557,0.0004336126,0.000208823,0.0002883066],"domain_scores_gemma":[0.9986955,0.000008941108,0.0001807156,0.0008806664,0.00004566076,0.0001885017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001167315,0.00139247,0.02029258,0.0005132611,0.001101296,0.00289801,0.0001952543,0.000005396415,0.8044484,0.001562942,0.0003249106,0.1660982],"study_design_scores_gemma":[0.007106507,0.0011016,0.9096169,0.0002574446,0.0004067156,0.0007709145,0.00003918872,0.001968036,0.07045425,0.006377405,0.001193002,0.0007079861],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886594,0.002660655,0.003809503,0.002360877,0.0006332606,0.0006370365,0.000006077943,0.0001025048,0.001130644],"genre_scores_gemma":[0.995663,0.00008997407,0.002229447,0.001624178,0.0001037796,0.00006330408,0.00001787253,0.00003963731,0.0001687586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8893244,"threshold_uncertainty_score":0.8317829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00894608005355912,"score_gpt":0.2691781747568647,"score_spread":0.2602320947033055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}