{"id":"W2735404270","doi":"10.1038/ng.3913","title":"Association analyses based on false discovery rate implicate new loci for coronary artery disease","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":794,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Heart Research Centre; University of Ottawa","funders":"NIHR Sheffield Biomedical Research Centre; European Regional Development Fund; Interreg; Pirkanmaan Rahasto; National Institutes of Health; Tays; Novo Nordisk Fonden; Diabetesliitto; Tampereen Tuberkuloosisäätiö; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Stockholms Läns Landsting; Knut och Alice Wallenbergs Stiftelse; Suomen Kulttuurirahasto; Karolinska Institutet; Novo Nordisk; Hjärt-Lungfonden; British Heart Foundation; National Institute for Health and Care Research; Imperial College Healthcare NHS Trust; Wellcome Trust; Canadian Institutes of Health Research; Yrjö Jahnssonin Säätiö; Pfizer; Biogen; European Commission; Sanofi; Torsten Söderbergs Stiftelse; Vetenskapsrådet; Emil Aaltosen Säätiö; AstraZeneca; Eli Lilly and Company; Sihtasutus Archimedes; Imperial College London; Andrea and Charles Bronfman Philanthropies","keywords":"Genome-wide association study; False discovery rate; Biology; Coronary artery disease; Genetic association; Genetics; Biobank; Multiple comparisons problem; Bioinformatics; Computational biology; Single-nucleotide polymorphism; Internal medicine; Medicine; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1163014,0.001702,0.002217398,0.004627794,0.001567053,0.004242198,0.004229667,0.003611807,0.002541427],"category_scores_gemma":[0.2020999,0.001251478,0.003721811,0.003201843,0.005025867,0.003734059,0.001790162,0.006829729,0.0004750157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008887508,"about_ca_system_score_gemma":0.00118123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101684,"about_ca_topic_score_gemma":0.0009721367,"domain_scores_codex":[0.923309,0.04629897,0.005616065,0.01032489,0.01234839,0.002102574],"domain_scores_gemma":[0.5006495,0.4350512,0.02342808,0.03297136,0.005519267,0.002380701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003803587,0.0003277482,0.8653775,0.0006522252,0.01547705,0.004338908,0.001115221,0.005790771,0.01398436,0.02386026,0.00276106,0.06251135],"study_design_scores_gemma":[0.0009264085,0.001637453,0.7083063,0.0003276456,0.009079289,0.01844885,0.0005802748,0.1204433,0.01803985,0.1167026,0.00520442,0.000303661],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5991595,0.009401958,0.3730449,0.007272956,0.002360732,0.0002143261,0.00115519,0.001543734,0.005846676],"genre_scores_gemma":[0.9735588,0.0005899078,0.02278735,0.00114216,0.0006346886,0.00007773501,0.0002425239,0.0002100135,0.0007568637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1163014,"threshold_uncertainty_score":0.6150678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523996204164289,"score_gpt":0.3362003564100584,"score_spread":0.3109603943684155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}