{"id":"W2735446066","doi":"10.1101/gad.298232.117","title":"From structure to mechanism—understanding initiation of DNA replication","year":2017,"lang":"en","type":"review","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Wellcome; Medical Research Council; Directorate for Biological Sciences; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Replication (statistics); Mechanism (biology); DNA replication; Origin recognition complex; Computational biology; Pre-replication complex; Genetics; DNA; Eukaryotic DNA replication; DNA replication factor CDT1; Control of chromosome duplication; Cell biology; Evolutionary biology; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006791691,0.0009191223,0.001101465,0.001569914,0.0004045393,0.001686474,0.00172835,0.001998661,0.002819324],"category_scores_gemma":[0.0007721606,0.0003185624,0.0004035196,0.001262606,0.001890132,0.003418356,0.001234757,0.003082762,0.002725174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001436846,"about_ca_system_score_gemma":0.001552866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261697,"about_ca_topic_score_gemma":0.0009365162,"domain_scores_codex":[0.9997463,0.00004211166,0.00002703749,0.00005772715,0.00009501392,0.0000318335],"domain_scores_gemma":[0.9996525,0.0001779819,0.00004161309,0.00001624642,0.0000728717,0.00003879203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006082668,0.00004669956,0.0002563756,0.02101992,0.00008910622,0.0003572239,0.0002505661,0.0008539212,0.005341672,0.05274666,0.06230724,0.8566698],"study_design_scores_gemma":[0.000003308975,0.00002679845,0.000212025,0.002056602,0.00002311973,0.0004929649,0.00005625583,0.00008086828,0.0005572473,0.01202388,0.984453,0.00001379326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000897702,0.9964281,0.0004515048,0.0009536151,0.0004389462,0.000003352805,0.00001749582,0.00001354597,0.001603727],"genre_scores_gemma":[0.0008306978,0.9973211,0.0003005545,0.0004317506,0.0003900679,0.000005285214,0.00002191634,0.00000299936,0.0006957308],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002819324,"threshold_uncertainty_score":0.01042509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09980972341585123,"score_gpt":0.3419121043622184,"score_spread":0.2421023809463672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}