{"id":"W2735446066","doi":"10.1101/gad.298232.117","title":"From structure to mechanism—understanding initiation of DNA replication","year":2017,"lang":"en","type":"review","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Wellcome; Medical Research Council; Directorate for Biological Sciences; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Replication (statistics); Mechanism (biology); DNA replication; Origin recognition complex; Computational biology; Pre-replication complex; Genetics; DNA; Eukaryotic DNA replication; DNA replication factor CDT1; Control of chromosome duplication; Cell biology; Evolutionary biology; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002378767,0.0003301511,0.000645978,0.0001105853,0.0001243763,0.00003765538,0.0004993405,0.0004238237,0.00003312916],"category_scores_gemma":[0.00008263185,0.0003126994,0.0001560563,0.00006692198,0.00001533489,0.000003900812,0.0003271079,0.00007600684,0.00001861453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805642,"about_ca_system_score_gemma":0.0005435215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006996319,"about_ca_topic_score_gemma":0.000027148,"domain_scores_codex":[0.998184,0.00006586928,0.0005593469,0.0007489016,0.0002305026,0.0002113692],"domain_scores_gemma":[0.9980049,0.00001086719,0.0006100098,0.001204098,0.0000815934,0.00008852639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009710549,0.00001517383,0.00000130915,0.001052257,0.0002652656,0.00000173927,0.0001449062,8.897635e-7,0.04264773,0.0004748954,0.0002784012,0.9551077],"study_design_scores_gemma":[0.00008689879,0.00003961398,0.000003945936,0.001075731,0.0001204845,0.000005861421,0.0000310889,5.709663e-7,0.1835814,0.001069965,0.813662,0.0003224936],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001617769,0.973029,0.02301855,0.00001879252,0.0006735385,0.001179509,0.0002106865,0.00002693455,0.0002252863],"genre_scores_gemma":[0.001839406,0.9686892,0.02534817,0.00005302847,0.0003386113,0.0001604592,0.003269994,0.00007557977,0.000225556],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9547852,"threshold_uncertainty_score":0.9999325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09980972341585123,"score_gpt":0.3419121043622184,"score_spread":0.2421023809463672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}