{"id":"W2735513607","doi":"10.1038/cddis.2017.319","title":"An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells","year":2017,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Health Canada; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Autocrine signalling; Paracrine signalling; Cancer research; Wnt signaling pathway; Cancer cell; Cancer stem cell; Biology; Breast cancer; Cancer; Immunology; Signal transduction; Medicine; Cell biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668694,0.0002062855,0.0002247583,0.0000447338,0.0004927823,0.00006262167,0.0002707648,0.00007710059,0.0004506939],"category_scores_gemma":[0.00002022077,0.0001392513,0.000107636,0.00002437127,0.0004340931,0.0002345324,0.00004797845,0.0001175144,0.00002300856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001854576,"about_ca_system_score_gemma":0.0001399597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004559501,"about_ca_topic_score_gemma":0.00002467959,"domain_scores_codex":[0.9989861,0.000148546,0.000281098,0.0002674279,0.00004838164,0.0002685046],"domain_scores_gemma":[0.9987918,0.00004927933,0.0002259734,0.0007813421,0.00007747232,0.00007410198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01950779,0.0003336133,0.1433838,0.0001982028,0.0001750523,0.00001878487,0.00139688,0.00001943313,0.8248122,0.0001034749,0.0006551492,0.00939557],"study_design_scores_gemma":[0.002088014,0.00008342956,0.8958842,0.00006170716,0.00008648727,0.000005511609,0.0002019028,0.00003275378,0.09653264,0.0001871202,0.004614261,0.0002219916],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858325,0.01282176,0.00001493988,0.0004027358,0.0002282761,0.0003121886,0.0002605331,0.00002751121,0.00009962597],"genre_scores_gemma":[0.9946715,0.0007842543,0.00001134473,0.0001859967,0.00002916554,0.0000623611,0.00003658676,0.00001954894,0.004199261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7525004,"threshold_uncertainty_score":0.5678504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005856021594193643,"score_gpt":0.2347696205322963,"score_spread":0.2289135989381027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}