{"id":"W2735543690","doi":"10.1152/ajpheart.00253.2017","title":"Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Oxidative stress; Pharmacology; Chemistry; Lipid peroxidation; Nitric oxide synthase; Inflammation; Cardiotoxicity; Doxorubicin; Vitamin C; Reactive oxygen species; Nitric oxide; Vitamin E; Proinflammatory cytokine; SOD2; Antioxidant; Superoxide dismutase; Endocrinology; Internal medicine; Biochemistry; Medicine; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003274557,0.0002254497,0.0009762495,0.0001960357,0.0001991216,0.00002339323,0.0001221237,0.0001293555,0.000008814769],"category_scores_gemma":[0.0001215855,0.0001962028,0.0001559383,0.00009082691,0.001025387,0.0002892065,0.00007815418,0.0004453501,0.000002156592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006176503,"about_ca_system_score_gemma":0.0001135112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007026458,"about_ca_topic_score_gemma":0.000007823526,"domain_scores_codex":[0.9985686,0.0002463912,0.0004163871,0.0003408729,0.000152367,0.0002753819],"domain_scores_gemma":[0.9985344,0.000130157,0.0006507554,0.000343225,0.0001825688,0.0001588487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000271964,0.00004985342,0.01192513,0.0000609403,0.0001737494,0.000002501949,0.0008512106,0.00001303616,0.9826293,0.00007518142,0.00001141473,0.003935699],"study_design_scores_gemma":[0.001331442,0.0006833205,0.6673149,0.000138245,0.00005441872,0.0001015147,0.0009732836,0.00003175333,0.3282883,0.0009190559,0.00004096333,0.0001228461],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986836,0.0001961904,0.000002512587,0.0006841834,0.0001369299,0.0002070608,0.000006364827,0.000009937973,0.0000732663],"genre_scores_gemma":[0.9987841,0.0002092355,0.0001333262,0.0003864792,0.0004464417,0.000008433323,0.000009284126,0.00001893724,0.00000382393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6553897,"threshold_uncertainty_score":0.8000917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277504526286791,"score_gpt":0.2654737596000085,"score_spread":0.2526987143371406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}