{"id":"W2735577846","doi":"10.1038/ncomms16014","title":"Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Michigan Diabetes Research Center, University of Michigan; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"mTORC1; PI3K/AKT/mTOR pathway; Cell biology; Autophagy; P70-S6 Kinase 1; Biology; Signal transduction; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872337,0.0006861832,0.0004115096,0.0004030877,0.0001611755,0.0004314838,0.0003072409,0.0003776212,0.001998557],"category_scores_gemma":[0.0001060356,0.0002928352,0.0003298145,0.0001946366,0.0004089419,0.0003172377,0.0002775894,0.000947438,0.0004904573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236487,"about_ca_system_score_gemma":0.0002182248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002957929,"about_ca_topic_score_gemma":0.0002709528,"domain_scores_codex":[0.9997715,0.00003869629,0.00002931738,0.00005213068,0.00005817006,0.00005012134],"domain_scores_gemma":[0.9998233,0.00001968122,0.00006479267,0.00002114913,0.000009186252,0.00006195167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003246622,0.00005314106,0.0002000626,0.00003594055,0.00001414948,0.0000630202,0.000005762048,0.0000808478,0.997574,0.0001394313,0.00008602552,0.00142299],"study_design_scores_gemma":[0.0000277278,0.0003813722,0.0035152,0.000008791374,0.00002799329,0.0005365356,0.0000189271,0.0006154739,0.992863,0.000086355,0.001914138,0.000004455235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921328,0.002089063,0.002889071,0.0002359077,0.00006734933,0.00001901158,0.0006300731,0.0002843019,0.001652482],"genre_scores_gemma":[0.9923266,0.001509446,0.00208225,0.0001185249,0.00002209513,0.00003541571,0.0005788686,0.00007870397,0.003248061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001998557,"threshold_uncertainty_score":0.006685793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02724797919380529,"score_gpt":0.314567912416935,"score_spread":0.2873199332231298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}