{"id":"W2735789032","doi":"10.1242/dev.149955","title":"Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud","year":2017,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society; Prostate Cancer Canada; Faculty of Medicine, McGill University; McGill University","keywords":"Mesoderm; Biology; FGF and mesoderm formation; Intermediate mesoderm; Brachyury; Cell biology; Paraxial mesoderm; NODAL; Progenitor cell; Noggin; Lateral plate mesoderm; Progenitor; Embryonic stem cell; Stem cell; Genetics; Bone morphogenetic protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009801133,0.0002153071,0.0001708977,0.0003964797,0.0002070185,0.0003888671,0.0001642952,0.0002261354,0.0007665345],"category_scores_gemma":[0.00009133168,0.0002363676,0.00013446,0.0001197008,0.0002434855,0.0001425594,0.0001926021,0.000444751,0.0003735269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289639,"about_ca_system_score_gemma":0.0001930515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006656541,"about_ca_topic_score_gemma":0.0009680346,"domain_scores_codex":[0.9999075,0.00001153554,0.000007581657,0.00001983586,0.00002918837,0.00002430537],"domain_scores_gemma":[0.9998819,0.00001330474,0.00002678946,0.00001438325,0.00001413428,0.00004940751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003616152,0.000003324255,0.0001845122,0.000005663426,8.242605e-7,0.00002708719,0.000006547222,0.000009530695,0.9994055,0.00008114862,0.000007619519,0.000231956],"study_design_scores_gemma":[0.00001566743,0.0001167779,0.01008546,0.000007826124,0.00001252186,0.0002007095,0.00003011859,0.000485516,0.9874378,0.00007853776,0.001526253,0.000002890019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99479,0.0008818246,0.001973293,0.00004503475,0.00001255557,0.00001453294,0.0004097347,0.00006780461,0.001805257],"genre_scores_gemma":[0.9926876,0.0004276123,0.001543067,0.00003293979,0.000007608392,0.00002531267,0.0004871787,0.00004279887,0.004746051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007665345,"threshold_uncertainty_score":0.002564371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076387244983701,"score_gpt":0.2914376142717799,"score_spread":0.2706737418219429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}