{"id":"W2735814320","doi":"10.1016/j.cell.2017.06.037","title":"Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; RNA splicing; Alternative splicing; Exon; RNA-binding protein; Genetics; Gene; Ribonucleoprotein; Exonic splicing enhancer; RNA; Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023642,0.0001027204,0.0001606684,0.00004010476,0.00008292434,0.00003299363,0.0003557311,0.0000832923,0.000007355161],"category_scores_gemma":[0.00009760464,0.00009142626,0.00006637458,0.00001555379,0.00009393422,0.000008144296,0.000157168,0.00007323366,0.000004704631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001968309,"about_ca_system_score_gemma":0.0000472346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971376,"about_ca_topic_score_gemma":0.0001096278,"domain_scores_codex":[0.9991398,0.00005468427,0.0001501782,0.0002355835,0.0001891485,0.0002305797],"domain_scores_gemma":[0.9992037,0.00001648665,0.0001516707,0.0004972623,0.00006444759,0.00006645833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114877,0.00004395494,0.03636611,0.00003165444,0.00001374994,0.00001022857,0.00003264427,0.0001241111,0.9619593,0.00002323591,0.0001593245,0.001120797],"study_design_scores_gemma":[0.001266772,0.0001131383,0.1083441,0.000056306,0.000004008981,0.000001316898,0.000106315,0.0005051688,0.8891361,0.00003699613,0.0003371793,0.00009251427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953503,0.0004821776,0.0004124809,0.00008054272,0.00007373375,0.0001794469,0.000009430363,0.000003127954,0.003408762],"genre_scores_gemma":[0.9977444,0.0001995585,0.00013941,0.00004283844,0.0000720823,0.000008249837,0.000007072339,0.00001112007,0.00177524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07282317,"threshold_uncertainty_score":0.3728255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090791975495282,"score_gpt":0.2932388135097848,"score_spread":0.272330893754832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}