{"id":"W2735814320","doi":"10.1016/j.cell.2017.06.037","title":"Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; RNA splicing; Alternative splicing; Exon; RNA-binding protein; Genetics; Gene; Ribonucleoprotein; Exonic splicing enhancer; RNA; Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000257271,0.0001968861,0.0001995279,0.000249185,0.0002394655,0.0004826965,0.0002728686,0.0002665927,0.0009641236],"category_scores_gemma":[0.0002362921,0.0002870075,0.0001993435,0.0001385231,0.0003843901,0.000266246,0.0005243876,0.0005059089,0.0004912335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003615173,"about_ca_system_score_gemma":0.0001154114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002109579,"about_ca_topic_score_gemma":0.0006332129,"domain_scores_codex":[0.9998482,0.00001905094,0.000009773327,0.0000741022,0.00002912394,0.00001974135],"domain_scores_gemma":[0.9997302,0.00005007809,0.0000685338,0.00005964624,0.00002868052,0.00006282415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004530817,0.000003967677,0.0004715184,0.000010351,0.000003913704,0.00009895931,0.00001851808,0.0001056382,0.9965562,0.0009606666,0.00006390939,0.001661121],"study_design_scores_gemma":[0.00004043048,0.0002379883,0.05201831,0.00001949564,0.0000702039,0.002020551,0.0001456841,0.00705395,0.9183558,0.002690422,0.01732477,0.00002251965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844263,0.001446364,0.01015926,0.0001801133,0.00005871576,0.000008140653,0.0001585084,0.0003080291,0.003254542],"genre_scores_gemma":[0.9934202,0.0001652587,0.004435085,0.0000949543,0.00004437277,0.00001023627,0.0002927692,0.00008273709,0.001454356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009641236,"threshold_uncertainty_score":0.003225327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02090791975495282,"score_gpt":0.2932388135097848,"score_spread":0.272330893754832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}