{"id":"W2735832888","doi":"10.1021/acs.jmedchem.7b00396","title":"A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Jewish General Hospital; University of Toronto; Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Society; Canada Foundation for Innovation; National Institute of Biomedical Imaging and Bioengineering; Weston Brain Institute; U.S. Department of Energy","keywords":"Kinome; Chemistry; In vivo; In vitro; Pharmacology; Neuroimaging; Neuroscience; Biochemistry; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004143527,0.0001604035,0.0006661153,0.0001762039,0.00009016291,0.00004080809,0.0001988721,0.000144915,0.00005067984],"category_scores_gemma":[0.01485169,0.0001381528,0.00006135758,0.0001009475,0.0002686792,0.0001367033,0.00005591484,0.0009510556,1.362859e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004541328,"about_ca_system_score_gemma":0.0006767454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006648019,"about_ca_topic_score_gemma":0.00007353759,"domain_scores_codex":[0.9977908,0.00009572965,0.0008050286,0.0002967388,0.0006897514,0.0003220204],"domain_scores_gemma":[0.9976211,0.001139031,0.0004061421,0.0002455709,0.0003153389,0.0002727861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004818936,0.0003492696,0.5589722,0.001222033,0.00006004561,0.0005244398,0.0006579414,0.000005989162,0.423957,6.698102e-7,0.001628934,0.007802488],"study_design_scores_gemma":[0.02457662,0.0007732178,0.4777079,0.004866012,0.0002491716,0.001181454,0.0005195683,0.003668838,0.4838079,0.0004405968,0.00192214,0.0002865494],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989222,0.002069045,0.000006064141,0.00767165,0.00007579055,0.0004585486,0.000004124186,0.000003088015,0.0004897271],"genre_scores_gemma":[0.9985552,0.0003475308,0.0002506489,0.0001164829,0.000590636,0.00005335351,0.000001005822,0.00002113364,0.00006396854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08126432,"threshold_uncertainty_score":0.9934466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207599078829096,"score_gpt":0.4165301395666692,"score_spread":0.3544541487783782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}