{"id":"W2735855176","doi":"10.1101/163998","title":"Interferon Regulatory Factor 5 (IRF5) Interacts with the Translation Initiation Complex and Promotes mRNA Translation During the Integrated Stress Response to Amino Acid Deprivation","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"National Institutes of Health","keywords":"IRF5; Interferon regulatory factors; Biology; Transcription factor; Translation (biology); Cell biology; Integrated stress response; ATF4; EIF4E; EIF4G; Regulation of gene expression; Cancer research; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004541714,0.0004385157,0.0002581194,0.0001507673,0.0004522535,0.0004301855,0.0004547893,0.0003236626,0.00001575767],"category_scores_gemma":[0.0002013019,0.000311163,0.00008940996,0.0001437323,0.0001826754,0.00005062097,0.0001574736,0.0003442013,0.000003999353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009425297,"about_ca_system_score_gemma":0.0002632145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001781861,"about_ca_topic_score_gemma":0.00004972921,"domain_scores_codex":[0.9978936,0.0004047762,0.0003852891,0.0007202948,0.0003148006,0.0002812799],"domain_scores_gemma":[0.9977915,0.00005369441,0.0004513987,0.001140539,0.0003930755,0.0001697565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001901374,0.00004962411,0.004719689,0.0001193006,0.00009864494,0.00000312492,0.0001411629,0.0001917303,0.9926444,0.000009024961,0.00003194033,0.00008998048],"study_design_scores_gemma":[0.0006146993,0.0001145976,0.5866802,0.0001977415,0.00005529442,7.001537e-8,0.00001644124,0.0005583668,0.410712,5.318349e-7,0.0007401604,0.0003099142],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924799,0.0004303515,0.003699207,0.001552966,0.0001630163,0.001322324,0.0002738571,0.00007350121,0.000004864634],"genre_scores_gemma":[0.9985926,0.00004611525,0.0007208496,0.0001580477,0.000207748,0.0001734252,0.00001836088,0.00007484141,0.000008036522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5819605,"threshold_uncertainty_score":0.999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224763718131985,"score_gpt":0.2422402552500608,"score_spread":0.2197638834368623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}