{"id":"W2735930784","doi":"10.1101/163535","title":"HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung","keywords":"Bisulfite sequencing; DNA methylation; Methylation; Computational biology; Locus (genetics); Epigenetics; CTCF; Biology; Genetics; Illumina Methylation Assay; DNA sequencing; DNA; Gene; Enhancer; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001978848,0.0009940653,0.0008385537,0.0009701502,0.0003767092,0.0009681894,0.000950759,0.0007794935,0.00268768],"category_scores_gemma":[0.001986481,0.0005933232,0.000504216,0.0005496332,0.000653363,0.0004683548,0.001103591,0.001131297,0.002071863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005939487,"about_ca_system_score_gemma":0.0006781704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162873,"about_ca_topic_score_gemma":0.002338039,"domain_scores_codex":[0.9981306,0.0004309249,0.0001195898,0.0005704876,0.0006457429,0.0001026158],"domain_scores_gemma":[0.9991762,0.0002312539,0.0001577792,0.0001737905,0.000193963,0.000067049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002017275,0.00003130329,0.001867706,0.0002028112,0.00009529186,0.00003922356,0.00008099618,0.002033544,0.9673382,0.001265595,0.001471293,0.02537234],"study_design_scores_gemma":[0.00001789893,0.0001192784,0.00224043,0.00001975818,0.00004350982,0.0001320807,0.00001885529,0.01427574,0.9706008,0.001034348,0.01146055,0.00003676404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1366265,0.002170332,0.8375802,0.0003946014,0.0002858494,0.0003480398,0.006273122,0.01291369,0.003407528],"genre_scores_gemma":[0.3275346,0.001215843,0.6529557,0.0003422784,0.0001057808,0.000687474,0.006703218,0.00108903,0.009366135],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00268768,"threshold_uncertainty_score":0.01046526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326839433964345,"score_gpt":0.263589575141554,"score_spread":0.2303211808019106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}