{"id":"W2735937324","doi":"10.1016/j.mehy.2017.07.013","title":"Implications of bisphosphonate calcium ion depletion interfering with desmosome epithelial seal in osseointegrated implants and pressure ulcers","year":2017,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Bone health and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"International Team for Implantology","keywords":"Desmosome; Calcium; Medicine; Bisphosphonate; Osteoporosis; Gap junction; Pressure sores; Internal medicine; Surgery; Chemistry; Cell biology; Biology; Intracellular; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857607,0.0001272162,0.0003080898,0.00007593531,0.0001193661,0.00001560112,0.0001039788,0.0001266492,0.0000813059],"category_scores_gemma":[0.0004075219,0.00008449698,0.00002669795,0.00006048662,0.0002614263,0.00008207619,0.00004152089,0.0002072613,0.000005016323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003587969,"about_ca_system_score_gemma":0.0001951922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003548396,"about_ca_topic_score_gemma":0.002425768,"domain_scores_codex":[0.9989939,0.00003295466,0.0002482726,0.000223718,0.0002541667,0.0002469723],"domain_scores_gemma":[0.9991255,0.0001065351,0.0001239628,0.0002929659,0.00005768696,0.0002933429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001347736,0.0002281498,0.9474029,0.0002343875,0.0001042876,0.0001063646,0.0002770581,8.992943e-7,0.002369292,0.0001451059,0.00005161683,0.04773223],"study_design_scores_gemma":[0.002797631,0.000406641,0.9867176,0.0006538986,0.00007324952,0.0002182521,0.00005103085,0.0001646135,0.008056523,0.0001294471,0.0006508839,0.0000802428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956483,0.0002314436,0.0001161567,0.002914633,0.0000726511,0.0003424621,0.00004376365,0.00002596359,0.0006046309],"genre_scores_gemma":[0.9992127,0.0001854621,0.0001967465,0.0001410257,0.00002544131,0.00004056723,0.00001616174,0.00001653898,0.0001653866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04765198,"threshold_uncertainty_score":0.5364137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03884384409048736,"score_gpt":0.3226878153319419,"score_spread":0.2838439712414545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}