{"id":"W2735976365","doi":"10.1111/hiv.12532","title":"Week 96 results of the randomized, multicentre Maraviroc Switch (<scp>MARCH</scp>) study","year":2017,"lang":"en","type":"article","venue":"HIV Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hip and Knee Clinic; AIDS Vancouver","funders":"Medical Research Council; Pfizer; Australian Government; Gilead Sciences; Department of Health and Aged Care, Australian Government; Meso Scale Diagnostics; AbbVie; GlaxoSmithKline; Merck; Thailand Research Fund; ViiV Healthcare; Bristol-Myers Squibb; University of New South Wales; Abbott Fund","keywords":"Maraviroc; Medicine; Regimen; Randomization; Randomized controlled trial; Internal medicine; Clinical endpoint; Confidence interval; Viral load; Ritonavir; CCR5 receptor antagonist; Population; Intention-to-treat analysis; Gastroenterology; Human immunodeficiency virus (HIV); Immunology; Antiretroviral therapy; Chemokine; Receptor; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001289035,0.0002044062,0.0007097013,0.00007415305,0.0004911614,0.00001106997,0.0007324461,0.0001101582,0.0001767171],"category_scores_gemma":[0.004987163,0.0001013692,0.000138019,0.00006402219,0.001266843,0.00004961126,0.0002918131,0.0003600753,0.0008567374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000297736,"about_ca_system_score_gemma":0.00007280395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001275534,"about_ca_topic_score_gemma":0.0003282875,"domain_scores_codex":[0.9979225,0.0006688721,0.0004885009,0.0003269654,0.0001571949,0.0004359639],"domain_scores_gemma":[0.9968724,0.001366109,0.0003586535,0.001226512,0.0001154221,0.0000609552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1232553,0.009213758,0.2123225,0.0002206216,0.007299386,0.0005242504,0.04330149,0.000005757471,0.0990992,0.0006108455,0.4772957,0.02685117],"study_design_scores_gemma":[0.7184282,0.001266352,0.1794657,0.000272492,0.0005683584,0.00003766796,0.005383232,0.00001194281,0.010099,0.000124467,0.084243,0.00009961452],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611903,0.002709112,0.00001763671,0.006601876,0.0008808645,0.002471309,0.0001648278,0.00003288992,0.02593121],"genre_scores_gemma":[0.9577356,0.0002211271,0.00001382858,0.00005960533,0.00008111546,0.00005597668,0.00009426194,0.00001314342,0.04172536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5951729,"threshold_uncertainty_score":0.9999212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427085731975139,"score_gpt":0.2941855971316036,"score_spread":0.2699147398118522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}