{"id":"W2736006326","doi":"10.1534/genetics.117.204222","title":"Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in<i>Caenorhabditis elegans</i>","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Caenorhabditis elegans; Proteostasis; Cell biology; Somatic cell; Gonad; Phenotype; Longevity; Transcription factor; Lysosome; Genetics; Gene; Endocrinology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008033997,0.0002654575,0.0001250498,0.0002192273,0.0001492323,0.0002347895,0.0001866658,0.0001757446,0.0006398336],"category_scores_gemma":[0.00008653447,0.0001107617,0.0001613004,0.00006503461,0.000220963,0.0001475841,0.0002090006,0.0002517368,0.0001699054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565197,"about_ca_system_score_gemma":0.0001557181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001517285,"about_ca_topic_score_gemma":0.002262509,"domain_scores_codex":[0.9999505,0.000003036224,0.000003933354,0.00001803207,0.00001002693,0.00001451097],"domain_scores_gemma":[0.9999149,0.000007304723,0.00003350342,0.000007625125,0.00001038432,0.0000263628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004473816,0.000008904846,0.0005262995,0.00001420653,0.000001414686,0.0000354656,0.000006647908,0.00004657564,0.9986458,0.00003787775,0.00004752081,0.000584463],"study_design_scores_gemma":[0.00001597267,0.0001280994,0.03962061,0.000009886333,0.00001355058,0.000183127,0.00005090254,0.002790451,0.9553518,0.0000874267,0.001736836,0.00001136276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958392,0.0004723262,0.001992206,0.00006367695,0.00002574365,0.00001213311,0.0004740821,0.0001278306,0.0009928468],"genre_scores_gemma":[0.9966301,0.0002533715,0.001309188,0.00004086087,0.000005117011,0.0000133526,0.0002441905,0.0000222109,0.001481507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517285,"threshold_uncertainty_score":0.003016949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539380284225723,"score_gpt":0.240995565905737,"score_spread":0.2256017630634798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}