{"id":"W2736023892","doi":"10.1016/j.mce.2017.07.011","title":"Epigenetics of pituitary tumors: Pathogenetic and therapeutic implications","year":2017,"lang":"en","type":"review","venue":"Molecular and Cellular Endocrinology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Epigenetics; Carcinogenesis; DNA methylation; microRNA; Biology; Histone; Pituitary tumors; Cancer research; Suppressor; Epigenesis; Gene; Cancer epigenetics; Tumor suppressor gene; Genetics; Bioinformatics; Gene expression; Histone methyltransferase; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00003547861,0.0003399277,0.001342821,0.0001565327,0.00009883185,0.00001126972,0.0001294905,0.000179848,0.00001708221],"category_scores_gemma":[0.00001527566,0.0002669187,0.0002488256,0.00005040974,0.0002563824,0.000009332759,0.0001242897,0.0001780482,0.000006392003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001255562,"about_ca_system_score_gemma":0.0001306877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003064285,"about_ca_topic_score_gemma":0.000002725276,"domain_scores_codex":[0.9986923,0.0000861206,0.0003853957,0.000433925,0.00008506505,0.0003171729],"domain_scores_gemma":[0.9988908,0.00003380801,0.0002117564,0.0006954245,0.00003658906,0.0001315776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008103905,0.0001524394,0.001045477,0.003816632,0.0005819957,0.0005535313,0.00001825174,6.623834e-8,0.0003072473,0.001132239,0.000006004388,0.992378],"study_design_scores_gemma":[0.002455508,0.001258571,0.002877037,0.002827376,0.009196225,0.003190473,0.00002922166,0.000004715694,0.0007324418,0.004204045,0.9725054,0.0007190132],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004114707,0.9938206,0.0002040059,0.00006647627,0.00004134813,0.0006770901,0.00005859682,0.00001528047,0.001001875],"genre_scores_gemma":[0.04769924,0.9516077,0.0001719348,0.0000509227,0.00002148237,0.00007945085,0.0002010594,0.00004105375,0.0001271683],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.991659,"threshold_uncertainty_score":0.9999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05165062769383715,"score_gpt":0.3309897377198457,"score_spread":0.2793391100260086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}