{"id":"W2736032762","doi":"10.1021/acs.jmedchem.6b00951","title":"Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Bone health and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Leading Edge Endowment Fund; Canada Foundation for Innovation","keywords":"Prodrug; Chemistry; In vivo; Conjugate; Bone resorption; Pharmacology; Cathepsin K; Bisphosphonate; Pharmacokinetics; Alendronic acid; Teriparatide; Osteoporosis; In vitro; Biochemistry; Internal medicine; Osteoclast; Calcium; Parathyroid hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702778,0.0002699881,0.0003336316,0.0001937932,0.0001099014,0.0002293193,0.0002212003,0.0003351402,0.0005715471],"category_scores_gemma":[0.0001379012,0.0002216122,0.0001472616,0.000120981,0.0001479629,0.0001821186,0.0001570813,0.0004049002,0.0002554298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014607,"about_ca_system_score_gemma":0.0003908905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004101856,"about_ca_topic_score_gemma":0.0007013658,"domain_scores_codex":[0.9999336,0.00001222217,0.00000563485,0.0000153866,0.00001901601,0.00001407671],"domain_scores_gemma":[0.9999626,0.000005911586,0.00001210533,0.000003249994,0.000007039429,0.000009031025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004261809,0.0001718806,0.0002794893,0.0001438398,0.00001211099,0.0002019659,0.00004047419,0.002206407,0.9665667,0.000850699,0.0001638656,0.02893633],"study_design_scores_gemma":[0.0004348413,0.004593282,0.00146338,0.00001869028,0.00005680171,0.0008845642,0.00001654192,0.006927814,0.9738582,0.0001813492,0.01154001,0.00002454482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391994,0.005592457,0.05030728,0.0003212366,0.00007330385,0.0006393135,0.0003338734,0.000149629,0.003383459],"genre_scores_gemma":[0.9611416,0.002497281,0.03203875,0.0001121423,0.0000226186,0.0002362829,0.0002606988,0.00002477741,0.003665739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005715471,"threshold_uncertainty_score":0.002187312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06230978558518115,"score_gpt":0.3640973382180717,"score_spread":0.3017875526328906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}