{"id":"W2736055518","doi":"10.2174/1389450118666170711151518","title":"PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials","year":2018,"lang":"en","type":"review","venue":"Current Drug Targets","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Olaparib; PARP inhibitor; Medicine; Ovarian cancer; Prostate cancer; Pancreatic cancer; Breast cancer; Clinical trial; Oncology; Cancer; Internal medicine; Cancer research; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001481129,0.0007038345,0.001754128,0.00197867,0.0002502221,0.001133904,0.001111246,0.001157805,0.00439572],"category_scores_gemma":[0.001877319,0.0002502466,0.00104427,0.002183513,0.0003998,0.001242277,0.0005213778,0.001818584,0.001062399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005317531,"about_ca_system_score_gemma":0.001469558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007979468,"about_ca_topic_score_gemma":0.001921122,"domain_scores_codex":[0.9996148,0.0000942605,0.00008814386,0.00004544845,0.0001321156,0.00002512419],"domain_scores_gemma":[0.9986797,0.0007156055,0.0001827052,0.00002734227,0.0003342847,0.00006023747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002003539,0.00008156941,0.0001565763,0.03354519,0.0001641571,0.0001087756,0.0000501443,0.0002489633,0.000609328,0.001858894,0.02383663,0.9391395],"study_design_scores_gemma":[0.0001250213,0.000350858,0.001146745,0.02700366,0.0008600256,0.00106087,0.00008943147,0.0001926993,0.000461393,0.001838829,0.966841,0.00002930618],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008360801,0.9990438,0.00004721502,0.0002495253,0.0001198452,0.0000074737,0.00001828735,0.000003592424,0.0004267302],"genre_scores_gemma":[0.000557101,0.9987116,0.0001545229,0.0002438353,0.0001150067,0.000009672492,0.00003089503,0.000001311391,0.000176152],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00439572,"threshold_uncertainty_score":0.01470518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2069710424431445,"score_gpt":0.5032244185833384,"score_spread":0.2962533761401939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}