{"id":"W2736124367","doi":"10.1016/j.fct.2017.07.028","title":"Evidence against an involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation","year":2017,"lang":"en","type":"letter","venue":"Food and Chemical Toxicology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Mitochondrial biogenesis; Mitochondrion; Chemistry; Oxidative stress; Resveratrol; Intracellular; Superoxide; Polyphenol; Biochemistry; Aryl hydrocarbon receptor; Benzo(a)pyrene; Neoplastic transformation; Mitochondrial ROS; Carcinogen; Carcinogenesis; Cell biology; Biology; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001234917,0.0003401767,0.0005856979,0.0002826451,0.001078912,0.001102692,0.0006544717,0.01017995,0.005467778],"category_scores_gemma":[0.005006086,0.0001967141,0.0005476351,0.0002279848,0.001591171,0.000878334,0.0006213769,0.01121409,0.002769905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001134701,"about_ca_system_score_gemma":0.0008413297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005468271,"about_ca_topic_score_gemma":0.0009923319,"domain_scores_codex":[0.9995121,0.0001291617,0.00006416427,0.00006290882,0.0001534188,0.00007811446],"domain_scores_gemma":[0.997112,0.001993158,0.0001679369,0.0001569669,0.000351248,0.000218665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001135336,0.0003566182,0.003083068,0.0002734124,0.00006552692,0.01392205,0.0001723318,0.0002310847,0.007870602,0.01661317,0.8679501,0.08832674],"study_design_scores_gemma":[0.0005867122,0.0004740844,0.003897744,0.0002118517,0.0000927158,0.007021333,0.0002744018,0.000808554,0.007140039,0.02152917,0.9579131,0.00005033665],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006715053,0.005284196,0.000467465,0.9532836,0.02584765,0.00002571263,0.0001205277,0.00007507596,0.008180609],"genre_scores_gemma":[0.08661778,0.01451634,0.001190674,0.7462351,0.1221934,0.0001217906,0.0002311057,0.00005435766,0.02883945],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01017995,"threshold_uncertainty_score":0.01829153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285147896573416,"score_gpt":0.2582361557433938,"score_spread":0.2297213660860522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}