{"id":"W2736169138","doi":"","title":"Inhibition of TDP-43 Aggregation using Native State Binding Ligands","year":2014,"lang":"en","type":"dissertation","venue":"TSpace","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer's Society; Government of Ontario","keywords":"Pathogenesis; Frontotemporal lobar degeneration; Protein aggregation; Oligonucleotide; Inclusion bodies; In vitro; Amyotrophic lateral sclerosis; Chemistry; Cell biology; Biology; Recombinant DNA; Biochemistry; DNA; Medicine; Gene; Disease; Frontotemporal dementia; Immunology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003144547,0.0002226543,0.0004708337,0.0003980297,0.00008319795,0.00002414847,0.00006278198,0.0002637836,0.0002086312],"category_scores_gemma":[0.00022628,0.0002000489,0.0001151693,0.0003913736,0.00005306484,0.00009488311,0.00002385585,0.0004312458,0.00003868257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068648,"about_ca_system_score_gemma":0.000232144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526463,"about_ca_topic_score_gemma":0.00008079335,"domain_scores_codex":[0.998285,0.00006057945,0.000355652,0.0003097836,0.0007108363,0.0002781249],"domain_scores_gemma":[0.9986779,0.00006490857,0.0004329177,0.0002267753,0.0004825169,0.0001149564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006559669,0.00007739493,0.0006651515,0.001114176,0.0001357993,0.00001837093,0.01000493,0.00006361187,0.980611,0.00006190598,0.0002835033,0.006308154],"study_design_scores_gemma":[0.002047992,0.0005827348,0.02252188,0.006084816,0.0002214821,0.00001034597,0.002375225,0.002502143,0.9627733,0.0002789944,0.0002008802,0.0004002653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948682,0.0001270741,0.0001590316,0.0001265885,0.0001899689,0.0005147584,0.000009175419,0.00004196861,0.003963208],"genre_scores_gemma":[0.9817919,0.0001559521,0.0003808936,0.0000228328,0.0001673713,0.00001582338,0.0009227313,0.00006331698,0.01647916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02185673,"threshold_uncertainty_score":0.8157756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04454409587568649,"score_gpt":0.3845515819111892,"score_spread":0.3400074860355027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}