{"id":"W2736356540","doi":"10.1001/jamapsychiatry.2017.1986","title":"Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases; National Cancer Institute; Institutionen för Integrativ Medicinsk Biologi, Umeå Universitet; Medical Research Council; National Institutes of Health; University of Pittsburgh; University of New South Wales; Centre for Cognitive Ageing and Cognitive Epidemiology; Terveyden ja hyvinvoinnin laitos; Max-Planck-Institut für Bildungsforschung; Hjartavernd; Haukeland Universitetssjukehus; Brigham and Women's Hospital; Stockholms Universitet; Karl-Franzens-Universität Graz; Menzies Institute for Medical Research; Háskóli Íslands; Johns Hopkins University; Universitetet i Oslo; National Institute of General Medical Sciences; Leids Universitair Medisch Centrum; Universitetet i Bergen; Samfundet Folkhälsan; Queensland Brain Institute; University of Queensland; Karolinska Institutet; Medizinische Universität Graz; Technische Universität Dresden; Monash University; University College Cork; National Institute of Mental Health; Hunter Medical Research Institute; Institut National de la Santé et de la Recherche Médicale; Universiteit Leiden; University of Glasgow; Biodiversity Institute, University of Florida; Umeå Universitet; Helsingin Yliopisto; School of Medicine, Boston University; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Broad Institute; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; Biotechnology and Biological Sciences Research Council; School of Public Health, University of Texas Health Science Center at Houston; Trinity College Dublin; Neuroscience Research Australia; Directorate for Biological Sciences; Imperial College London; University of Texas Health Science Center at Houston; Wellcome Trust; Sveučilište u Zagrebu; Rush University; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of Washington","keywords":"Cognition; Schizophrenia (object-oriented programming); Genome-wide association study; Psychology; Genomics; Genetic association; Clinical psychology; Genetics; Psychiatry; Biology; Genome; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001570205,0.0007071233,0.0004325472,0.001580415,0.000442102,0.0006516215,0.0005208552,0.0007032892,0.002152952],"category_scores_gemma":[0.005325874,0.000278704,0.001043065,0.001618243,0.0006544443,0.0002121018,0.0006404662,0.0005495177,0.0001467791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004903972,"about_ca_system_score_gemma":0.00100397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009247676,"about_ca_topic_score_gemma":0.01156763,"domain_scores_codex":[0.9989167,0.0002738858,0.0001369974,0.0003531457,0.0001767564,0.0001425423],"domain_scores_gemma":[0.9958979,0.001625245,0.001757698,0.0002633975,0.0001632527,0.0002924589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002572424,0.0001078723,0.9771917,0.00009552552,0.001162242,0.0008352824,0.0002218681,0.000976723,0.0102971,0.000221903,0.0001723312,0.006144994],"study_design_scores_gemma":[0.0001410225,0.0002075132,0.9944278,0.00003625529,0.0006506877,0.0008578083,0.0001010122,0.001696544,0.001390573,0.0003364309,0.0001345723,0.00001979013],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983969,0.0002210104,0.000547005,0.00003991068,0.000004074551,0.00001258977,0.0006222443,0.000009393243,0.000146845],"genre_scores_gemma":[0.9980723,0.0001116484,0.001002929,0.00001378354,0.000006002137,0.0000195805,0.0006447582,0.000004658804,0.000124503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009247676,"threshold_uncertainty_score":0.01838768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005526890238758458,"score_gpt":0.2451152636636841,"score_spread":0.2395883734249257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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