{"id":"W2736356540","doi":"10.1001/jamapsychiatry.2017.1986","title":"Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases; National Cancer Institute; Institutionen för Integrativ Medicinsk Biologi, Umeå Universitet; Medical Research Council; National Institutes of Health; University of Pittsburgh; University of New South Wales; Centre for Cognitive Ageing and Cognitive Epidemiology; Terveyden ja hyvinvoinnin laitos; Max-Planck-Institut für Bildungsforschung; Hjartavernd; Haukeland Universitetssjukehus; Brigham and Women's Hospital; Stockholms Universitet; Karl-Franzens-Universität Graz; Menzies Institute for Medical Research; Háskóli Íslands; Johns Hopkins University; Universitetet i Oslo; National Institute of General Medical Sciences; Leids Universitair Medisch Centrum; Universitetet i Bergen; Samfundet Folkhälsan; Queensland Brain Institute; University of Queensland; Karolinska Institutet; Medizinische Universität Graz; Technische Universität Dresden; Monash University; University College Cork; National Institute of Mental Health; Hunter Medical Research Institute; Institut National de la Santé et de la Recherche Médicale; Universiteit Leiden; University of Glasgow; Biodiversity Institute, University of Florida; Umeå Universitet; Helsingin Yliopisto; School of Medicine, Boston University; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Broad Institute; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; Biotechnology and Biological Sciences Research Council; School of Public Health, University of Texas Health Science Center at Houston; Trinity College Dublin; Neuroscience Research Australia; Directorate for Biological Sciences; Imperial College London; University of Texas Health Science Center at Houston; Wellcome Trust; Sveučilište u Zagrebu; Rush University; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of Washington","keywords":"Cognition; Schizophrenia (object-oriented programming); Genome-wide association study; Psychology; Genomics; Genetic association; Clinical psychology; Genetics; Psychiatry; Biology; Genome; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005502401,0.0001229445,0.0002276892,0.00003565219,0.000282569,0.00003091004,0.00008754582,0.0001954323,0.000003118662],"category_scores_gemma":[0.0009863825,0.000101422,0.00007376663,0.00004054106,0.0003596071,0.00001262904,0.00006986035,0.0001324937,0.000002305226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005423446,"about_ca_system_score_gemma":0.00006328192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002088406,"about_ca_topic_score_gemma":0.0000455012,"domain_scores_codex":[0.9988561,0.0002318707,0.0003937639,0.0002898992,0.00009502023,0.0001333814],"domain_scores_gemma":[0.9985913,0.00006312363,0.0009033848,0.0001978008,0.000200192,0.00004422185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004180403,0.0001627079,0.6855727,0.00008075383,0.0008638905,3.948469e-7,0.0005364013,0.00005272438,0.1954605,0.0005718872,0.001062298,0.1114553],"study_design_scores_gemma":[0.002830276,0.0002184979,0.9924909,0.00003913464,0.0003117748,0.00001114237,0.0002184654,0.001365233,0.001485477,0.0008804522,0.00004275334,0.000105873],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948889,0.001662969,0.002559494,0.0002210472,0.0001444098,0.0002170334,0.00007318414,0.000004333845,0.0002286316],"genre_scores_gemma":[0.9978861,0.0005650825,0.001047659,0.000102629,0.0002393353,0.00001764319,0.00004898292,0.00001233322,0.00008023673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3069182,"threshold_uncertainty_score":0.4135867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005526890238758458,"score_gpt":0.2451152636636841,"score_spread":0.2395883734249257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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