{"id":"W2736381792","doi":"10.1002/pro.3227","title":"Crystal structure of the UBR‐box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding","year":2017,"lang":"en","type":"article","venue":"Protein Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Zinc finger; Chemistry; Monomer; DNA ligase; Residue (chemistry); Crystal structure; Zinc; Ubiquitin; Stereochemistry; Crystallography; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005484744,0.0001487979,0.0001485048,0.00003050426,0.0007835135,0.0001315577,0.001532564,0.0001229227,0.00006873031],"category_scores_gemma":[0.0008517581,0.0001066492,0.00006487652,0.0001407637,0.000925138,0.00002153993,0.0006447515,0.0001409184,0.00000613219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001944988,"about_ca_system_score_gemma":0.00017638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215544,"about_ca_topic_score_gemma":0.00002810604,"domain_scores_codex":[0.9984996,0.00007262619,0.0002165608,0.0004619906,0.0004088788,0.0003402885],"domain_scores_gemma":[0.9984947,0.00001301116,0.0003577371,0.0009334275,0.0001005848,0.0001005208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001372684,0.000009311526,0.002635716,0.00001198292,0.000007401019,5.228333e-7,0.0000987559,6.339516e-7,0.9966465,0.00009514815,0.0001420484,0.0003383109],"study_design_scores_gemma":[0.0002592602,0.00004873587,0.002643713,0.00007630239,0.000003970986,0.000002513233,0.00005525105,0.000010558,0.9924776,0.001588138,0.002684181,0.0001497936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967507,0.0002554356,0.0003000703,0.0002680288,0.0001629833,0.0005016404,0.0003196723,0.000009056247,0.00143238],"genre_scores_gemma":[0.9973518,0.000008026109,0.002093061,0.00008010634,0.00011011,0.00001829379,0.00002316747,0.00001163461,0.0003038209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00416886,"threshold_uncertainty_score":0.6026231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125599074626497,"score_gpt":0.2503691294312896,"score_spread":0.2378092219686399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}