{"id":"W2736414404","doi":"10.1080/15384101.2017.1346758","title":"p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs","year":2017,"lang":"en","type":"article","venue":"Cell Cycle","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; Heart and Stroke Foundation; University of Toronto; University Health Network; Toronto General Hospital; York University","funders":"","keywords":"Biology; Downregulation and upregulation; Cell biology; Cell cycle; microRNA; Cell growth; Gene knockdown; Cell cycle checkpoint; Mdm2; Cell; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001823142,0.0001582657,0.0002449407,0.00001343937,0.0002356606,0.00007224585,0.0002217203,0.0001183711,0.000008243479],"category_scores_gemma":[0.00004054681,0.0001538592,0.00007973748,0.00003819219,0.0001933505,0.000008226855,0.0002357316,0.00007074137,0.000007012834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000139295,"about_ca_system_score_gemma":0.00005698996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001908049,"about_ca_topic_score_gemma":0.00003385764,"domain_scores_codex":[0.9990062,0.00004566797,0.0001820529,0.0003852485,0.00009559535,0.0002852373],"domain_scores_gemma":[0.9989486,0.00001893356,0.000121049,0.0006954587,0.00006776486,0.00014821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001866773,0.00008404621,0.005572205,0.0001371169,0.000129043,0.00001123074,0.0002231048,0.0008350177,0.9732049,0.0004199044,0.005916583,0.01328022],"study_design_scores_gemma":[0.001399644,0.0003664458,0.07851602,0.00005941745,0.0002107083,0.000005469665,0.0002741672,0.0001307259,0.7462198,0.001103053,0.1709617,0.0007528652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855708,0.005874405,0.001140041,0.0002272046,0.0002322126,0.0002038268,0.00009553412,0.000006822294,0.006649157],"genre_scores_gemma":[0.9934939,0.003933261,0.001790867,0.0001132551,0.0003109049,0.00002740706,0.00002948619,0.00002567353,0.0002753116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2269851,"threshold_uncertainty_score":0.6274197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007242112728327707,"score_gpt":0.2432783762980841,"score_spread":0.2360362635697564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}