{"id":"W2736472010","doi":"10.1038/npp.2017.124","title":"Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice","year":2017,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"5-HT2C receptor; Nucleus accumbens; Agonist; Microdialysis; Chemistry; Pharmacology; Dopamine; Antagonist; Receptor antagonist; Inverse agonist; Neuroscience; Receptor; Psychology; 5-HT receptor; Serotonin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005229095,0.001910263,0.001079151,0.002174597,0.0007069272,0.000886577,0.001148153,0.001820765,0.00430304],"category_scores_gemma":[0.0002943153,0.0009234868,0.001053891,0.0004980701,0.002153194,0.0008457595,0.0005821452,0.004597631,0.0009967573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001330599,"about_ca_system_score_gemma":0.0008574178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00491052,"about_ca_topic_score_gemma":0.01534466,"domain_scores_codex":[0.9989257,0.0001094036,0.0001021479,0.0003126825,0.0002323265,0.0003176032],"domain_scores_gemma":[0.9987304,0.00009965618,0.0003945265,0.0001111273,0.00006091401,0.000603278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001558513,0.0003697437,0.0002030352,0.00002820854,0.00002193994,0.0001192092,0.00003690286,0.0000779965,0.9966825,0.0001523061,0.00008911005,0.0006606237],"study_design_scores_gemma":[0.0004715559,0.002298718,0.01063493,0.00003071381,0.0001153876,0.0003284865,0.0001388699,0.001688896,0.983054,0.0001909453,0.001003761,0.00004373772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941621,0.0004909549,0.001397369,0.0004518862,0.0001064643,0.00006456488,0.002053529,0.0002348067,0.001038261],"genre_scores_gemma":[0.9771321,0.0009896704,0.005877445,0.0006630975,0.00009808964,0.0003448968,0.001977445,0.0004052468,0.01251194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00491052,"threshold_uncertainty_score":0.01439512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07103832949462045,"score_gpt":0.3805856847977396,"score_spread":0.3095473553031191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}