{"id":"W2736738987","doi":"10.1080/21505594.2017.1356539","title":"Selective inhibition of host cell signaling for rotavirus antivirals: PI3K/Akt/mTOR-mediated rotavirus pathogenesis","year":2017,"lang":"en","type":"letter","venue":"Virulence","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"PI3K/AKT/mTOR pathway; Rotavirus; Autophagy; Protein kinase B; Biology; Virology; Pathogenesis; Signal transduction; Immunology; Virus; Cell biology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006561261,0.0003365422,0.0005040353,0.0001887431,0.0007824633,0.00119534,0.0003030032,0.006613698,0.0032544],"category_scores_gemma":[0.00344376,0.0001420547,0.0004177753,0.0001527356,0.0008927104,0.0009310521,0.000536393,0.009630723,0.002537464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001337135,"about_ca_system_score_gemma":0.0008190126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003297513,"about_ca_topic_score_gemma":0.0006465526,"domain_scores_codex":[0.9994972,0.0001609312,0.00006174906,0.00005745554,0.0001349664,0.00008764835],"domain_scores_gemma":[0.9989962,0.0005003483,0.0001017402,0.00004804888,0.0002285286,0.0001251507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004655563,0.0002096345,0.004710027,0.0003817569,0.00005886095,0.02468172,0.0002555726,0.0002417392,0.007534964,0.0158106,0.8520392,0.09361037],"study_design_scores_gemma":[0.0002149786,0.0002499867,0.003363928,0.0002786996,0.00004387083,0.01855199,0.0004105627,0.0008500866,0.003845614,0.01188372,0.9602711,0.00003551752],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.009172779,0.0109895,0.0007420592,0.9388255,0.02744067,0.00002621159,0.00009970097,0.00008711148,0.01261644],"genre_scores_gemma":[0.1567644,0.02572373,0.001898257,0.6199432,0.1588221,0.0001245455,0.0001949085,0.00006191596,0.03646688],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006613698,"threshold_uncertainty_score":0.01088709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04537885463987206,"score_gpt":0.3203553413070035,"score_spread":0.2749764866671314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}