{"id":"W2736800350","doi":"10.1210/en.2017-00436","title":"ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells","year":2017,"lang":"en","type":"article","venue":"Endocrinology","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; China Scholarship Council","keywords":"Bone morphogenetic protein 2; Downregulation and upregulation; BMPR2; Gene knockdown; Internal medicine; Bone morphogenetic protein; Endocrinology; Chemistry; Cell biology; Activin receptor; PTX3; Biology; Signal transduction; Cell culture; Medicine; Biochemistry; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981585,0.000230302,0.0002799802,0.0001877521,0.0001770969,0.0002972894,0.0001542115,0.0002445714,0.001797745],"category_scores_gemma":[0.0001039209,0.0001547055,0.0003589672,0.000126591,0.0001984385,0.0001596738,0.0001906101,0.0005266615,0.0005529515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103505,"about_ca_system_score_gemma":0.0002823138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007525389,"about_ca_topic_score_gemma":0.0008986626,"domain_scores_codex":[0.9998448,0.00002921275,0.00001631249,0.0000251508,0.00004715978,0.00003727576],"domain_scores_gemma":[0.9999536,0.000006821181,0.00001414896,0.00000702109,0.000005810571,0.00001247844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002082659,0.00002987527,0.0002395837,0.00008979379,0.00001358009,0.0001151223,0.00002396542,0.00006342552,0.9979359,0.000134313,0.00008958688,0.001056626],"study_design_scores_gemma":[0.00009888378,0.0002881971,0.008109223,0.00001047759,0.00004658701,0.0005467084,0.00008756165,0.001841937,0.9810867,0.00007916612,0.007799207,0.000005510073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899682,0.004004141,0.003116771,0.0002265668,0.00007149177,0.00008117218,0.0005771652,0.00009201769,0.001862381],"genre_scores_gemma":[0.9911472,0.001699484,0.002219632,0.0001266138,0.00002065522,0.00009696896,0.001018508,0.0000175932,0.003653269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797745,"threshold_uncertainty_score":0.006014049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976102489561031,"score_gpt":0.2774643228654069,"score_spread":0.2577032979697966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}