{"id":"W2736830325","doi":"10.1038/nchem.2814","title":"The versatility of boron in biological target engagement","year":2017,"lang":"en","type":"review","venue":"Nature Chemistry","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":323,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Electrophile; Boron; Heteroatom; Covalent bond; Nucleophile; Combinatorial chemistry; Small molecule; Molecule; Nanotechnology; Organic chemistry; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0006428561,0.0007095691,0.001721488,0.00002023939,0.0002350584,0.00007582785,0.0021561,0.003411189,0.002089034],"category_scores_gemma":[0.001489628,0.0004734568,0.0006840784,0.0001234054,0.0004534218,0.00004272757,0.0005402341,0.004430384,0.00001778045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400264,"about_ca_system_score_gemma":0.000570636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006550014,"about_ca_topic_score_gemma":0.000002695525,"domain_scores_codex":[0.9971103,0.00006021969,0.001009719,0.0008401889,0.0004189433,0.0005606347],"domain_scores_gemma":[0.9961252,0.0005680278,0.0009944523,0.002085385,0.00008053298,0.0001464404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008045347,0.0005469968,0.0006976721,0.1054612,0.0006041044,0.0001352442,0.00008115164,1.939484e-7,0.02194405,0.0000365879,0.00688262,0.8635297],"study_design_scores_gemma":[0.0002491908,0.000002971491,0.000008703537,0.002875698,0.00009551521,0.00001338269,0.00003800722,6.028591e-7,0.1649546,0.00002565775,0.8313659,0.0003697494],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006172808,0.9749936,1.19358e-7,0.00004550825,0.0001879639,0.000152429,0.0002622422,0.00006213965,0.02367873],"genre_scores_gemma":[0.005358131,0.9923281,0.00003626522,0.00001232429,0.0004510374,0.00006242531,0.0004004435,0.00006175794,0.001289504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.86316,"threshold_uncertainty_score":0.9997717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06055435737116516,"score_gpt":0.3582294397454131,"score_spread":0.2976750823742479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}