{"id":"W2736837914","doi":"10.1016/j.neuroimage.2017.07.036","title":"Imaging-wide association study: Integrating imaging endophenotypes in GWAS","year":2017,"lang":"en","type":"article","venue":"NeuroImage","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Aging; Minnesota Supercomputing Institute, University of Minnesota; University of California, San Diego; National Institutes of Health; Servier; Fujirebio Europe; Eisai; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; Pfizer; BioClinica; University of Minnesota; IXICO; Takeda Pharmaceutical Company; Medpace; Genentech; Biogen Idec; Health Research; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Takeda Pharmaceuticals North America; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Synarc; University of Southern California; Roche; Alzheimer's Drug Discovery Foundation; Merck; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Endophenotype; Genome-wide association study; Neuroimaging; Genetic association; Imaging genetics; Association (psychology); Statistical power; Computational biology; Computer science; Neuroscience; Psychology; Biology; Gene; Genetics; Cognition; Single-nucleotide polymorphism; Genotype; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01083757,0.0009958887,0.001874665,0.00277451,0.0008634087,0.003317072,0.001545349,0.002077699,0.001975382],"category_scores_gemma":[0.02228079,0.0007591441,0.002446243,0.005271496,0.0007621559,0.001444825,0.002104961,0.001567541,0.0003867971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344922,"about_ca_system_score_gemma":0.000860282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005079782,"about_ca_topic_score_gemma":0.007865584,"domain_scores_codex":[0.9889416,0.00698097,0.0006832089,0.002311139,0.0007499318,0.0003332274],"domain_scores_gemma":[0.9878235,0.00635998,0.00145421,0.00310234,0.0008239542,0.0004360271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001200736,0.0001574982,0.9428304,0.0001961138,0.01093084,0.0005321512,0.0002645862,0.001242333,0.007417882,0.002365646,0.00233818,0.03052371],"study_design_scores_gemma":[0.000259384,0.0004029397,0.9605223,0.0001101124,0.009496527,0.001356122,0.0003812447,0.008155889,0.002636896,0.01083392,0.005757658,0.00008698631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8586909,0.01208631,0.113078,0.003140679,0.0003997163,0.0001682688,0.006770652,0.0006909372,0.004974477],"genre_scores_gemma":[0.9609671,0.001217942,0.033935,0.000644998,0.0002274766,0.0001486807,0.001862219,0.0001977642,0.0007989121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01083757,"threshold_uncertainty_score":0.05731523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335977474788738,"score_gpt":0.2902024754292704,"score_spread":0.2768427006813829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}