{"id":"W2736848649","doi":"10.1007/s10545-017-0069-8","title":"Loss of sirtuin 4 leads to elevated glucose‐ and leucine‐stimulated insulin levels and accelerated age‐induced insulin resistance in multiple murine genetic backgrounds","year":2017,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; Canadian Institutes of Health Research; American Diabetes Association; American Heart Association; National Institutes of Health; Canadian Diabetes Association; Vanderbilt University","keywords":"Insulin resistance; Biology; Insulin; Sirtuin; Endocrinology; Internal medicine; Leucine; Lysine; Metabolism; Carbohydrate metabolism; Lipid metabolism; Sirtuin 1; Biochemistry; Acetylation; Amino acid; Medicine; Gene; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435046,0.001107958,0.0004616631,0.001507922,0.0002987532,0.0004776114,0.0005235526,0.0008198008,0.003123865],"category_scores_gemma":[0.0002415677,0.0006083443,0.0008191527,0.0005358015,0.0006233286,0.0003861628,0.0005402016,0.001269971,0.0007440378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005594656,"about_ca_system_score_gemma":0.0003064584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097114,"about_ca_topic_score_gemma":0.00170214,"domain_scores_codex":[0.999401,0.00008573743,0.00009363179,0.0001782886,0.0001425351,0.00009887357],"domain_scores_gemma":[0.9991435,0.000069079,0.0003919717,0.00007869561,0.00004528099,0.0002714772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004271733,0.00007206517,0.0003720577,0.00003093762,0.00002249897,0.0001310085,0.00002801532,0.00009888874,0.9978057,0.0001266663,0.00005271235,0.0008323154],"study_design_scores_gemma":[0.0001668819,0.00177962,0.02347665,0.00003758059,0.0001542287,0.001153974,0.000125492,0.002471094,0.9657236,0.0002683919,0.004600392,0.00004202381],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908749,0.001336152,0.004472336,0.0002315873,0.00008796262,0.00005449995,0.001392587,0.0003802456,0.001169644],"genre_scores_gemma":[0.9768913,0.00185552,0.006988974,0.000232187,0.00005091797,0.0001501606,0.002168455,0.0002716994,0.01139079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123865,"threshold_uncertainty_score":0.01045042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05549388515587358,"score_gpt":0.3203566329514201,"score_spread":0.2648627477955465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}