{"id":"W2737154013","doi":"10.1161/hypertensionaha.117.09438","title":"Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney","year":2017,"lang":"en","type":"article","venue":"Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; Uppsala Multidisciplinary Center for Advanced Computational Science; Münchner Zentrum für Gesundheitswissenschaften; Agència de Gestió d'Ajuts Universitaris i de Recerca; Erasmus Universitair Medisch Centrum Rotterdam; Cambridge Institute for Medical Research, University of Cambridge; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; Centre for Cognitive Ageing and Cognitive Epidemiology; Mutuelle Générale de l'Education Nationale; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; Academy of Finland; Servier; Karl-Franzens-Universität Graz; Paavo Nurmen Säätiö; Sigrid Juséliuksen Säätiö; Université de Bordeaux; Universitair Medisch Centrum Groningen; Sydäntutkimussäätiö; Provincia autonoma di Bolzano - Alto Adige; Schweizerische Herzstiftung; National Institute for Health Research Health Protection Research Unit; Vetenskapsrådet; Fondation de France; Signe ja Ane Gyllenbergin Säätiö; Reuter Foundation; Juho Vainion Säätiö; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Turun Yliopistollinen Keskussairaala; Suomen Kulttuurirahasto; Diabetes Fonds; Erasmus Medisch Centrum; Diabetesliitto; Sanofi; Leids Universitair Medisch Centrum; Nierstichting; Svenska Sällskapet för Medicinsk Forskning; Fondation pour la Recherche Médicale; Amgen; Fondazione Cariplo; Yrjö Jahnssonin Säätiö; Kela; National Institute of General Medical Sciences; Orionin Tutkimussäätiö; Eesti Teadusagentuur; Age UK; Hrvatska Zaklada za Znanost; Russian Foundation for Basic Research; National Eye Institute; Public Health England; Foundation for Cardiovascular Research; ZonMw; National Heart, Lung, and Blood Institute; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; Fondation Leducq; National Institute on Aging; Universität Greifswald; Medical Research Council; Hjärt-Lungfonden; University of Dundee; Johns Hopkins University; Home Office; Wellcome Trust; Agence Nationale de la Recherche; Wetenschappelijk Onderzoek- en Documentatiecentrum; University of Edinburgh; Universität Basel; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; European Science Foundation; Terveyden ja hyvinvoinnin laitos; Imperial College London; King's College London; Generalitat de Catalunya; European Commission; Knut och Alice Wallenbergs Stiftelse; NIHR Cambridge Biomedical Research Centre; Scottish Funding Council; Hôpitaux Universitaires de Genève; China Scholarship Council; British Heart Foundation; Austrian Science Fund; National Institute for Health and Care Research; AstraZeneca; Ministry of Cultural Affairs; Medizinische Universität Graz; Emil Aaltosen Säätiö; Compagnia di San Paolo; MRC-PHE Centre for Environment and Health; Bristol-Myers Squibb; Helsingin Yliopisto; Vrije Universiteit Amsterdam; Understanding Society; Scottish Government; Imperial College Healthcare NHS Trust; Cancer Research UK; University of Essex; Juvenile Diabetes Research Foundation International; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Universitätsspital Basel; Wake Forest University; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Tampereen Tuberkuloosisäätiö; Rijksuniversiteit Groningen; University of Leicester; National Institute of Diabetes and Digestive and Kidney Diseases; Royal Society; Foundation for the National Institutes of Health; Pfizer","keywords":"Blood pressure; Genome-wide association study; Locus (genetics); Gene; Biology; Genetics; Computational biology; Genetic association; Bioinformatics; Medicine; Endocrinology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006229448,0.0001513025,0.0002653617,0.00001584858,0.0005917928,0.0001377393,0.0002205808,0.0001880586,0.000001322376],"category_scores_gemma":[0.001999361,0.0001045908,0.00002280318,0.00001387234,0.0001023181,0.00002414686,0.001020985,0.00009688028,2.914481e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000032227,"about_ca_system_score_gemma":0.00003227775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006769263,"about_ca_topic_score_gemma":0.00007678441,"domain_scores_codex":[0.9988061,0.0001610105,0.0002006883,0.0005323245,0.0001158284,0.0001840424],"domain_scores_gemma":[0.9985747,0.0001366204,0.0002907738,0.0008487285,0.00006687248,0.00008226687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005880684,0.0001234565,0.4327042,0.000005760377,0.0003173111,0.000002643537,0.00008436126,0.000009767949,0.5660365,8.409443e-7,0.0005020636,0.0001543481],"study_design_scores_gemma":[0.006300336,0.0001459569,0.9812603,0.00002949245,0.00169056,0.00003069013,0.0002052077,0.002097946,0.006439304,0.0001022584,0.001439962,0.0002580025],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937586,0.00440486,0.0003776338,0.0007902438,0.0001042666,0.0002990543,0.000242624,0.000004861486,0.00001787041],"genre_scores_gemma":[0.9959161,0.001257257,0.001732662,0.000541723,0.0001617628,0.000006326598,0.0002554856,0.0000157009,0.0001130246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5595971,"threshold_uncertainty_score":0.4551651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545243055894054,"score_gpt":0.2655476628161423,"score_spread":0.2300952322572018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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