{"id":"W2737154013","doi":"10.1161/hypertensionaha.117.09438","title":"Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney","year":2017,"lang":"en","type":"article","venue":"Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; Uppsala Multidisciplinary Center for Advanced Computational Science; Münchner Zentrum für Gesundheitswissenschaften; Agència de Gestió d'Ajuts Universitaris i de Recerca; Erasmus Universitair Medisch Centrum Rotterdam; Cambridge Institute for Medical Research, University of Cambridge; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; Centre for Cognitive Ageing and Cognitive Epidemiology; Mutuelle Générale de l'Education Nationale; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; Academy of Finland; Servier; Karl-Franzens-Universität Graz; Paavo Nurmen Säätiö; Sigrid Juséliuksen Säätiö; Université de Bordeaux; Universitair Medisch Centrum Groningen; Sydäntutkimussäätiö; Provincia autonoma di Bolzano - Alto Adige; Schweizerische Herzstiftung; National Institute for Health Research Health Protection Research Unit; Vetenskapsrådet; Fondation de France; Signe ja Ane Gyllenbergin Säätiö; Reuter Foundation; Juho Vainion Säätiö; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Turun Yliopistollinen Keskussairaala; Suomen Kulttuurirahasto; Diabetes Fonds; Erasmus Medisch Centrum; Diabetesliitto; Sanofi; Leids Universitair Medisch Centrum; Nierstichting; Svenska Sällskapet för Medicinsk Forskning; Fondation pour la Recherche Médicale; Amgen; Fondazione Cariplo; Yrjö Jahnssonin Säätiö; Kela; National Institute of General Medical Sciences; Orionin Tutkimussäätiö; Eesti Teadusagentuur; Age UK; Hrvatska Zaklada za Znanost; Russian Foundation for Basic Research; National Eye Institute; Public Health England; Foundation for Cardiovascular Research; ZonMw; National Heart, Lung, and Blood Institute; Universiteit Leiden; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; Fondation Leducq; National Institute on Aging; Universität Greifswald; Medical Research Council; Hjärt-Lungfonden; University of Dundee; Johns Hopkins University; Home Office; Wellcome Trust; Agence Nationale de la Recherche; Wetenschappelijk Onderzoek- en Documentatiecentrum; University of Edinburgh; Universität Basel; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; European Science Foundation; Terveyden ja hyvinvoinnin laitos; Imperial College London; King's College London; Generalitat de Catalunya; European Commission; Knut och Alice Wallenbergs Stiftelse; NIHR Cambridge Biomedical Research Centre; Scottish Funding Council; Hôpitaux Universitaires de Genève; China Scholarship Council; British Heart Foundation; Austrian Science Fund; National Institute for Health and Care Research; AstraZeneca; Ministry of Cultural Affairs; Medizinische Universität Graz; Emil Aaltosen Säätiö; Compagnia di San Paolo; MRC-PHE Centre for Environment and Health; Bristol-Myers Squibb; Helsingin Yliopisto; Vrije Universiteit Amsterdam; Understanding Society; Scottish Government; Imperial College Healthcare NHS Trust; Cancer Research UK; University of Essex; Juvenile Diabetes Research Foundation International; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Universitätsspital Basel; Wake Forest University; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Tampereen Tuberkuloosisäätiö; Rijksuniversiteit Groningen; University of Leicester; National Institute of Diabetes and Digestive and Kidney Diseases; Royal Society; Foundation for the National Institutes of Health; Pfizer","keywords":"Blood pressure; Genome-wide association study; Locus (genetics); Gene; Biology; Genetics; Computational biology; Genetic association; Bioinformatics; Medicine; Endocrinology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001995576,0.0002978613,0.0007258201,0.001659246,0.000578667,0.0009032238,0.0005034267,0.0003613228,0.00111473],"category_scores_gemma":[0.004173204,0.0002570341,0.001006735,0.002855411,0.0003034767,0.0002049668,0.0008123016,0.0005386627,0.0002082398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261646,"about_ca_system_score_gemma":0.0006552575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005294668,"about_ca_topic_score_gemma":0.01054725,"domain_scores_codex":[0.9981331,0.0005895073,0.0001796353,0.0006148401,0.000291719,0.0001911048],"domain_scores_gemma":[0.9978639,0.00119336,0.0003150946,0.0003205481,0.0001220893,0.0001849456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001062359,0.0001237799,0.9158682,0.0001124476,0.002058233,0.001357823,0.0004554536,0.001261855,0.05859859,0.0004333949,0.0005789021,0.0180889],"study_design_scores_gemma":[0.0001079219,0.0001068827,0.9879665,0.00001827829,0.0008163959,0.0008800984,0.0001396328,0.003940819,0.004082421,0.0004644177,0.001445557,0.00003099467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934673,0.0001967269,0.00427926,0.00005725468,0.000005759693,0.00002153134,0.001654112,0.0000258301,0.0002923113],"genre_scores_gemma":[0.9897236,0.000118008,0.006438279,0.00004946321,0.00001131412,0.00005316952,0.003376425,0.00002121466,0.0002084619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005294668,"threshold_uncertainty_score":0.01055378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545243055894054,"score_gpt":0.2655476628161423,"score_spread":0.2300952322572018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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