{"id":"W2737167849","doi":"10.1038/s41598-017-07153-4","title":"Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Foundation Fighting Blindness","keywords":"Biology; Rhodopsin; Frameshift mutation; CRISPR; Xenopus; Genetics; Retinitis pigmentosa; Genome editing; PAX6; Cas9; Gene; Point mutation; Retinal degeneration; Phenotype; Computational biology; Mutation; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774206,0.0005555684,0.0002960923,0.0004551547,0.000291606,0.0004853811,0.0005117028,0.0004423148,0.0009175377],"category_scores_gemma":[0.0001623367,0.00036361,0.0005188292,0.0001597914,0.000485852,0.0002286509,0.0004654553,0.0006122849,0.0003046592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004861908,"about_ca_system_score_gemma":0.0003790249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600727,"about_ca_topic_score_gemma":0.001867544,"domain_scores_codex":[0.9997509,0.00003864526,0.00003861255,0.00005824719,0.00008066279,0.00003291625],"domain_scores_gemma":[0.9998072,0.00003696049,0.00008706311,0.00002481152,0.00001203896,0.00003204223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003298681,0.00001817381,0.0001541452,0.00002508365,0.000006835069,0.0001378716,0.00002623525,0.0005740214,0.9978129,0.0003931373,0.00001934031,0.00079936],"study_design_scores_gemma":[0.00003691704,0.0001771682,0.001259409,0.00001357279,0.00003832985,0.0007797935,0.00003617149,0.00374488,0.9893619,0.0002032068,0.004333684,0.000015004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9395451,0.0008832949,0.05477036,0.0001734891,0.00006319318,0.0001881361,0.0006661072,0.0005916005,0.003118818],"genre_scores_gemma":[0.9504385,0.001332456,0.04194481,0.00005624634,0.00001170737,0.0001948431,0.0004320061,0.0002065882,0.005382915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600727,"threshold_uncertainty_score":0.003527582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068600277742256,"score_gpt":0.3173876766272612,"score_spread":0.2967016738498386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}