{"id":"W2737184167","doi":"10.1021/acs.jmedchem.7b00164","title":"Structure–Activity Study of Ghrelin(1–8) Resulting in High Affinity Fluorine-Bearing Ligands for the Ghrelin Receptor","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Western University; Canada Foundation for Innovation; Prostate Cancer Canada; Ontario Ministry of Research, Innovation and Science; Government of Canada","keywords":"Ghrelin; Chemistry; Receptor; Growth hormone secretagogue receptor; Ligand (biochemistry); Secretagogue; Endocrinology; Internal medicine; In vivo; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838268,0.0002616397,0.000286067,0.00009460432,0.00009305653,0.0001161142,0.000246051,0.0002564562,0.001010857],"category_scores_gemma":[0.0001448153,0.0001388133,0.0001986604,0.0000935176,0.0001270089,0.0001628064,0.0000992142,0.0003114129,0.0001996431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776553,"about_ca_system_score_gemma":0.0001263503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008484344,"about_ca_topic_score_gemma":0.001113099,"domain_scores_codex":[0.9999173,0.00002259217,0.000004318754,0.0000161815,0.00001647707,0.00002317761],"domain_scores_gemma":[0.9999545,0.00001118326,0.00001600784,0.000003029788,0.000006272164,0.000009038982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004030579,0.0001614408,0.0001086386,0.00007020923,0.00001694421,0.0000802637,0.00003368457,0.001488658,0.9944848,0.0001435829,0.00007790019,0.002930643],"study_design_scores_gemma":[0.0002066692,0.0067236,0.002713709,0.00001036811,0.0000650123,0.0004395852,0.00002030674,0.00394823,0.9825999,0.00003812942,0.003210431,0.00002405687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996586,0.001204302,0.001000441,0.00004574078,0.000011437,0.00004014355,0.00009444694,0.00002210717,0.0009954303],"genre_scores_gemma":[0.9957086,0.0008540593,0.002038735,0.00003234133,0.000006402433,0.00002170657,0.0001673794,0.000006385086,0.001164377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010857,"threshold_uncertainty_score":0.00338167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04029727422342179,"score_gpt":0.3138493930402118,"score_spread":0.27355211881679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}