{"id":"W2737341911","doi":"10.1371/journal.pone.0181535","title":"Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Cairo University","keywords":"Cardiotoxicity; Medicine; Resveratrol; Doxorubicin; Pharmacology; Therapeutic effect; Adjuvant; Cardiac function curve; Apoptosis; Toxicity; Chemotherapy; Therapeutic index; Heart failure; Immunology; Internal medicine; Drug; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820027,0.0002420283,0.0006225462,0.0001296418,0.000268302,0.00008191253,0.0001597198,0.0001956544,0.0000409384],"category_scores_gemma":[0.0002711061,0.0002249094,0.0002107839,0.0001158233,0.00009960384,0.0004637209,0.00004436396,0.0003384742,0.00001601569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024322,"about_ca_system_score_gemma":0.0001110091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001835261,"about_ca_topic_score_gemma":0.00001723827,"domain_scores_codex":[0.9981656,0.0001242593,0.0003266098,0.000388055,0.0007126825,0.0002827752],"domain_scores_gemma":[0.9982106,0.00009765102,0.0003631991,0.0008311283,0.0003711753,0.0001262213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005994772,0.0006583161,0.01888512,0.0004509352,0.001037568,0.00001125879,0.00182152,0.000001474188,0.9728599,0.00002523996,0.00002498964,0.003624205],"study_design_scores_gemma":[0.002866799,0.0005711465,0.1805966,0.0002937115,0.0005558492,0.00000335438,0.0001489989,0.0001875254,0.814564,0.00003580901,0.000009898054,0.0001662838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950925,0.00008611454,0.00003730321,0.001169987,0.00006061484,0.002735621,0.00006628561,0.00005528978,0.0006962637],"genre_scores_gemma":[0.9980937,0.00007606481,0.000249741,0.0007610412,0.0002544736,0.0001567401,0.00005659704,0.00004697412,0.0003046237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1617115,"threshold_uncertainty_score":0.9171538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08260751189077531,"score_gpt":0.3084053133275096,"score_spread":0.2257978014367343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}