{"id":"W2737623654","doi":"10.1007/s00401-017-1752-4","title":"Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":248,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McMaster University; Kingston General Hospital; London Health Sciences Centre; McGill University; University of Ottawa; University of Alberta; Hospital for Sick Children; Université de Montréal; Dalhousie University; Centre Hospitalier Universitaire Sainte-Justine; BC Children's Hospital; Children's & Women's Health Centre of British Columbia; Alberta Children's Hospital; Stollery Children's Hospital; University of British Columbia; SickKids Foundation; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Matthew Larson Foundation for Pediatric Brain Tumors; Sidney Kimmel Foundation for Cancer Research; National Cancer Institute; Doris Duke Charitable Foundation","keywords":"Ependymoma; Immunohistochemistry; Immunostaining; Pathology; Medicine; Posterior fossa; Cohort; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458624,0.0001850201,0.0007019964,0.000157794,0.00006267088,0.00002114588,0.0001662088,0.0001172139,0.00004714222],"category_scores_gemma":[0.0003196541,0.0001405558,0.0002104513,0.0002282494,0.0002845076,0.00009221587,0.0001451056,0.0001169942,0.000001510049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003850351,"about_ca_system_score_gemma":0.00001770506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001260248,"about_ca_topic_score_gemma":0.000007734106,"domain_scores_codex":[0.9986562,0.00006007952,0.0005069787,0.0003944179,0.0001907251,0.000191602],"domain_scores_gemma":[0.9987798,0.00003592243,0.000397326,0.0006397747,0.00006255799,0.00008463816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001926337,0.000818587,0.8164031,0.00002202955,0.0001467196,0.0004059195,0.0001383366,2.557643e-7,0.18052,0.00001877375,0.00001209928,0.001321494],"study_design_scores_gemma":[0.001436751,0.0008462879,0.9836053,0.00004534548,0.001030916,0.0006790526,0.0000437948,0.00002735785,0.012144,0.00004514418,0.000005932743,0.00009007981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978737,0.0003539555,0.000001150196,0.0007858492,0.00007274671,0.0003116197,0.0001319002,0.00001752799,0.0004515792],"genre_scores_gemma":[0.9995564,0.00008077096,0.000237607,0.00005894036,0.00001482933,0.00001313896,0.00002407218,0.000008185156,0.000006103917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.168376,"threshold_uncertainty_score":0.5731699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794365866560254,"score_gpt":0.2948879284135733,"score_spread":0.2769442697479708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}