{"id":"W2737691094","doi":"10.1016/j.parkreldis.2017.07.018","title":"Motor subtype changes in early Parkinson's disease","year":2017,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Movement Disorders","funders":"National Institute of Nursing Research; Sanofi Genzyme; UCB US; Allergan; Peabody College; GE Healthcare; Genentech; Ipsen; Servier; Frances C. and William P. Smallwood Foundation; Merck; NeuroPace; Avid Radiopharmaceuticals; Parkinson Alliance; Michael J. Fox Foundation for Parkinson's Research; Boston Scientific Corporation; Vanderbilt University; University of Florida Foundation; AbbVie; National Center for Advancing Translational Sciences; Teva Pharmaceutical Industries; National Institutes of Health; Medtronic; GlaxoSmithKline; Biogen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Tourette Association of America; Roche","keywords":"Parkinson's disease; Disease; Clinical phenotype; Medicine; Movement disorders; Hierarchical clustering; Internal medicine; Gait; Physical medicine and rehabilitation; Psychology; Phenotype; Cluster analysis; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003610398,0.0002535131,0.0006197084,0.001023079,0.0004443782,0.0007132989,0.0003669165,0.0004645242,0.002779945],"category_scores_gemma":[0.000656599,0.0001535734,0.0002733315,0.000659142,0.0002515415,0.0005301443,0.0002872923,0.0004253541,0.0005072955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006268928,"about_ca_system_score_gemma":0.0003041339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009538361,"about_ca_topic_score_gemma":0.01561088,"domain_scores_codex":[0.9998944,0.00001820654,0.0000169598,0.00001676949,0.0000307412,0.00002297115],"domain_scores_gemma":[0.9996517,0.0000475294,0.0001357936,0.00001238092,0.00009067716,0.00006182283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004588998,0.0004216125,0.7851145,0.0005698805,0.0001817956,0.01906317,0.0006914121,0.0004014837,0.02601558,0.000780152,0.002347829,0.1598237],"study_design_scores_gemma":[0.00005051277,0.000475805,0.9793353,0.0001126424,0.00006396059,0.01454167,0.0005154698,0.000352965,0.001223613,0.0004863302,0.002829535,0.00001222016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681221,0.01541422,0.0004054251,0.0004189409,0.00005307077,0.00005590879,0.0005084035,0.00002974018,0.01499206],"genre_scores_gemma":[0.9884573,0.005282649,0.0005461239,0.0001494421,0.00006630329,0.00001535443,0.0004667478,0.000011648,0.005004379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009538361,"threshold_uncertainty_score":0.01896566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289783476961272,"score_gpt":0.257792739905327,"score_spread":0.2448949051357143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}