{"id":"W2737691094","doi":"10.1016/j.parkreldis.2017.07.018","title":"Motor subtype changes in early Parkinson's disease","year":2017,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Movement Disorders","funders":"National Institute of Nursing Research; Sanofi Genzyme; UCB US; Allergan; Peabody College; GE Healthcare; Genentech; Ipsen; Servier; Frances C. and William P. Smallwood Foundation; Merck; NeuroPace; Avid Radiopharmaceuticals; Parkinson Alliance; Michael J. Fox Foundation for Parkinson's Research; Boston Scientific Corporation; Vanderbilt University; University of Florida Foundation; AbbVie; National Center for Advancing Translational Sciences; Teva Pharmaceutical Industries; National Institutes of Health; Medtronic; GlaxoSmithKline; Biogen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Tourette Association of America; Roche","keywords":"Parkinson's disease; Disease; Clinical phenotype; Medicine; Movement disorders; Hierarchical clustering; Internal medicine; Gait; Physical medicine and rehabilitation; Psychology; Phenotype; Cluster analysis; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002579905,0.0005168309,0.00058595,0.0003557397,0.0005964078,0.000174304,0.0004413215,0.0002822091,0.0003067385],"category_scores_gemma":[0.0002783801,0.0004886829,0.00028002,0.0001952821,0.000251934,0.0002890953,0.000159236,0.000437132,0.0004128554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768147,"about_ca_system_score_gemma":0.0002175602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008223483,"about_ca_topic_score_gemma":0.0005002006,"domain_scores_codex":[0.9971629,0.00009578498,0.0003896076,0.0009421375,0.0005430779,0.0008664411],"domain_scores_gemma":[0.9973351,0.00005240771,0.000333159,0.00140066,0.00006236184,0.0008162955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002582382,0.002227393,0.7862964,0.0001703831,0.0005935697,0.00172814,0.0006802322,0.00001522274,0.0008189544,0.001530757,0.0004325195,0.2029241],"study_design_scores_gemma":[0.004832482,0.0002792049,0.6385596,0.0001614905,0.0002397534,0.000007468546,0.00004008451,0.0004465697,0.0001541794,0.004018889,0.3508843,0.0003759288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816757,0.003495248,0.00002735998,0.004192368,0.0006228351,0.001120463,0.00007401564,0.000222185,0.00856984],"genre_scores_gemma":[0.9933206,0.003236154,0.0003249128,0.0003509617,0.00008304575,0.0002793254,0.00006097039,0.0001098052,0.002234211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3504518,"threshold_uncertainty_score":0.9997565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289783476961272,"score_gpt":0.257792739905327,"score_spread":0.2448949051357143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}