{"id":"W2737892378","doi":"","title":"Rpe65 knockout prevents T4K rhodopsin-induced retinal degeneration in a transgenic X. laevis model of retinitis pigmentosa","year":2017,"lang":"en","type":"article","venue":"","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Retinitis pigmentosa; RPE65; Gene therapy of the human retina; Rhodopsin; Retinal degeneration; Transgene; Retinal regeneration; Genetically modified mouse; Retinal; Ophthalmology; Degeneration (medical); Biology; Medicine; Genetics; Retinal pigment epithelium; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004262206,0.0007442619,0.00046572,0.001196643,0.0004559079,0.0007164208,0.0005007939,0.001008475,0.003195753],"category_scores_gemma":[0.0002249935,0.0005595829,0.0005224783,0.0002666433,0.0008129443,0.0005315352,0.0004978196,0.001422253,0.001034685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004738796,"about_ca_system_score_gemma":0.0004470742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002485008,"about_ca_topic_score_gemma":0.003331233,"domain_scores_codex":[0.999467,0.0000777298,0.0001023446,0.0001192683,0.0001095115,0.0001242187],"domain_scores_gemma":[0.9992742,0.00007358999,0.0003306723,0.00005946606,0.00003894992,0.0002231316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586836,0.00007670446,0.0001370657,0.00002914879,0.00001029743,0.0001444933,0.00003072892,0.00005196755,0.9985268,0.0002129503,0.00004252537,0.0005784957],"study_design_scores_gemma":[0.00009442592,0.0004422723,0.008600079,0.0000477349,0.00006859975,0.0007396348,0.0002067822,0.001213985,0.9859383,0.000199474,0.002427169,0.00002156507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939529,0.001069959,0.002186234,0.0002471787,0.00008720764,0.00003295659,0.0005244196,0.0003970817,0.001502],"genre_scores_gemma":[0.9852349,0.0009566417,0.002073346,0.00009153187,0.00002401245,0.00005360624,0.000427577,0.000179651,0.01095875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003195753,"threshold_uncertainty_score":0.01069087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699743525046056,"score_gpt":0.2919499573843733,"score_spread":0.2549525221339128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}