{"id":"W2737895828","doi":"10.1161/res.117.suppl_1.187","title":"Abstract 187: Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto","funders":"","keywords":"Bafilomycin; Autophagy; Phospholamban; Cell biology; Lysosome; Chloroquine; ATG5; Chemistry; SERCA; Biguanide; LAMP1; Endogeny; Endoplasmic reticulum; ATPase; Metformin; Biology; Biochemistry; Endocrinology; Apoptosis; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276273,0.0003797328,0.0003375705,0.0001933643,0.0001560709,0.0002509357,0.0001990597,0.0002887504,0.002967252],"category_scores_gemma":[0.0001243017,0.0001495508,0.0002550981,0.0001450324,0.0002047736,0.000289512,0.0001692783,0.0006225161,0.0004236246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462503,"about_ca_system_score_gemma":0.0003615856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000369178,"about_ca_topic_score_gemma":0.0005047519,"domain_scores_codex":[0.9998976,0.00001834873,0.00001758992,0.00002267385,0.00002095167,0.00002278594],"domain_scores_gemma":[0.9999404,0.000007771231,0.00001861601,0.000006746124,0.000006172246,0.00002024087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00100839,0.00008542949,0.0001642952,0.00008895258,0.00001084964,0.00007113838,0.000006839129,0.00004891629,0.9963017,0.00009645615,0.0001958367,0.001921259],"study_design_scores_gemma":[0.0001402632,0.0006989193,0.003471259,0.000008666135,0.00002886889,0.0001063652,0.00001107577,0.0005185512,0.9933961,0.00004044711,0.001575704,0.000003824664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925741,0.002334663,0.001711401,0.0003115931,0.0001465728,0.0000376671,0.0007269715,0.0001459887,0.002010911],"genre_scores_gemma":[0.9903724,0.001604451,0.001897557,0.0002345726,0.0000697842,0.0001004898,0.0009321106,0.00004405854,0.004744495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002967252,"threshold_uncertainty_score":0.009926379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0814205318378643,"score_gpt":0.3570064566492174,"score_spread":0.2755859248113531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}