{"id":"W2737956513","doi":"10.1007/s00467-017-3744-y","title":"The role of von Willebrand factor in thrombotic microangiopathy","year":2017,"lang":"en","type":"review","venue":"Pediatric Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Thrombotic microangiopathy; Von Willebrand factor; Thrombotic thrombocytopenic purpura; Atypical hemolytic uremic syndrome; Complement system; ADAMTS13; Immunology; Medicine; Alternative complement pathway; Microangiopathic hemolytic anemia; Eculizumab; Factor H; Disease; Platelet; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004223987,0.0004781882,0.002237769,0.0003989361,0.0002693116,0.00002224051,0.001371745,0.0006480431,0.0003927697],"category_scores_gemma":[0.0002571593,0.0003218163,0.0006167215,0.0001950066,0.0003379402,0.00004989923,0.0004109009,0.0005216122,0.0005664001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007202323,"about_ca_system_score_gemma":0.0003967123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001067862,"about_ca_topic_score_gemma":0.0001113053,"domain_scores_codex":[0.9965747,0.0009825159,0.001196499,0.0005224858,0.00005608103,0.0006677282],"domain_scores_gemma":[0.9959782,0.001451965,0.001342841,0.00114281,0.00005484867,0.00002933983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008417165,0.0002642529,0.01510647,0.005283327,0.0008450455,0.00002076699,0.0001757391,2.699537e-7,0.00009420836,0.0005140251,0.005953246,0.9716585],"study_design_scores_gemma":[0.000466271,0.0001001128,0.001528536,0.0002549669,0.0009248929,0.00006113117,0.00002055829,1.19134e-7,0.000004474332,0.0002141978,0.9961613,0.0002633751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002699303,0.9942887,8.682078e-7,0.00002027719,0.001218464,0.001162694,0.0002751876,0.0000308047,0.0003036774],"genre_scores_gemma":[0.00675874,0.9922726,0.000004468935,0.00001377188,0.0002630342,0.0001904723,0.0001471842,0.0000453803,0.0003044039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9902081,"threshold_uncertainty_score":0.9999234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856013267860858,"score_gpt":0.3168387473164939,"score_spread":0.2782786146378853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}